PMID- 8950356
OWN - NLM
STAT- MEDLINE
DCOM- 19970102
LR  - 20190702
IS  - 0027-5107 (Print)
IS  - 0027-5107 (Linking)
VI  - 371
IP  - 1-2
DP  - 1996 Nov 4
TI  - Analysis of lymphocytes from uranium mineworkers in Namibia for chromosomal 
      damage using fluorescence in situ hybridization (FISH).
PG  - 109-13
AB  - Workers in the open pit uranium mine in Namibia appear to suffer from health 
      problems including malignant diseases at a much higher prevalence when compared 
      with the general population. The objective of the present study was to determine 
      whether long-term exposure to low-dose uranium increases the risk of biological 
      radiation damage which could lead to malignant diseases. In order to investigate 
      this risk, we measured the relative frequency of chromosome alterations using 
      Fluorescence in situ hybridization (FISH). A representative cohort of 11 
      non-smoking miners, were compared to a control group of 9 individuals with no 
      occupational history in mining. We determined a significant increase in 
      chromosome aberrations in the circulating lymphocytes of miners versus the 
      non-smoking controls (p = 0.0000096). Therefore, we concluded that these uranium 
      exposed miners are at an increased risk to acquire genetic damage, which may be 
      associated with an increased risk for malignant transformation.
FAU - Zaire, R
AU  - Zaire R
AD  - Department of Hematology, University Medical Center Benjamin Franklin, Free 
      University Berlin, Germany.
FAU - Griffin, C S
AU  - Griffin CS
FAU - Simpson, P J
AU  - Simpson PJ
FAU - Papworth, D G
AU  - Papworth DG
FAU - Savage, J R
AU  - Savage JR
FAU - Armstrong, S
AU  - Armstrong S
FAU - Hulten, M A
AU  - Hulten MA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Mutat Res
JT  - Mutation research
JID - 0400763
RN  - 4OC371KSTK (Uranium)
SB  - IM
MH  - Adult
MH  - *Chromosome Aberrations
MH  - Cohort Studies
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Lymphocytes/*drug effects
MH  - Middle Aged
MH  - *Mining
MH  - Namibia
MH  - *Occupational Exposure
MH  - Uranium/*toxicity
EDAT- 1996/11/04 00:00
MHDA- 1996/11/04 00:01
CRDT- 1996/11/04 00:00
PHST- 1996/11/04 00:00 [pubmed]
PHST- 1996/11/04 00:01 [medline]
PHST- 1996/11/04 00:00 [entrez]
AID - S0165-1218(96)90100-7 [pii]
AID - 10.1016/s0165-1218(96)90100-7 [doi]
PST - ppublish
SO  - Mutat Res. 1996 Nov 4;371(1-2):109-13. doi: 10.1016/s0165-1218(96)90100-7.