PMID- 8953895
OWN - NLM
STAT- MEDLINE
DCOM- 19961231
LR  - 20151008
IS  - 0029-0203 (Print)
IS  - 0029-0203 (Linking)
VI  - 100
IP  - 11
DP  - 1996 Nov
TI  - [T lymphocyte subsets in aqueous humor from patients with uveitis].
PG  - 899-904
AB  - We studied T lymphocyte subsets in the aqueous humor (AH) and peripheral blood 
      (PB) from patients with active uveitis using three-color flow cytometry. We 
      assessed the number of T lymphocyte subsets that stained with 
      fluorescence-conjugated anti-CD3, CD4, CD8, CD29, CD45RA, CD45RO, and HLA (human 
      leukocyte antigen)-DR monoclonal antibodies in the AH and PB from 32 patients: 9 
      with sarcoidosis (SAR), 6 with Vogt-Koyanagi-Harade disease (VKH), 4 with 
      HLA-B27+ uveitis, 2 with Behcet's disease, 2 with diabetic iritis, 9 with 
      idiopathic uveitis, and 10 healthy control subjects. The percentage of CD3+ 
      lymphocytes was significantly higher in uveitic AH than in PB. The percentage of 
      CD4+ lymphocytes was significantly higher in uveitic AH than in PB in SAR. While 
      the percentage of CD4+CD45RA+ (naive) cells within T cells was much lower in 
      uveitic AH than in PB, the percentage of CD4+CD29+ or CD4+CD45RO+ (memory) cells 
      was significantly higher. There was no significant difference in these subsets in 
      PB between patients and controls. The results suggest that an increase in the 
      number of activated memory T lymphocytes in AH is involved in the pathogenesis of 
      uveitis.
FAU - Ohta, K
AU  - Ohta K
AD  - Department of Ophthalmology, Shinshu University School of Medicine, Nagano-ken, 
      Japan.
LA  - jpn
PT  - English Abstract
PT  - Journal Article
PL  - Japan
TA  - Nippon Ganka Gakkai Zasshi
JT  - Nippon Ganka Gakkai zasshi
JID - 7505716
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aqueous Humor/*immunology
MH  - CD4-CD8 Ratio
MH  - Female
MH  - Flow Cytometry
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *T-Lymphocyte Subsets
MH  - Uveitis/*immunology
EDAT- 1996/11/01 00:00
MHDA- 1996/11/01 00:01
CRDT- 1996/11/01 00:00
PHST- 1996/11/01 00:00 [pubmed]
PHST- 1996/11/01 00:01 [medline]
PHST- 1996/11/01 00:00 [entrez]
PST - ppublish
SO  - Nippon Ganka Gakkai Zasshi. 1996 Nov;100(11):899-904.