PMID- 8954798
OWN - NLM
STAT- MEDLINE
DCOM- 19970325
LR  - 20190905
IS  - 0888-7543 (Print)
IS  - 0888-7543 (Linking)
VI  - 38
IP  - 2
DP  - 1996 Dec 1
TI  - A 1.5-megabase physical map encompassing the multiple endocrine neoplasia type-1 
      (MEN1) locus on chromosome 11q13.
PG  - 166-73
AB  - Linkage analysis and loss of heterozygosity studies have shown that the gene 
      responsible for the multiple endocrine neoplasia type-1 (MEN1) syndrome localizes 
      to a small interval between D11S427 and D11S460 on chromosome 11q13. As an 
      initial step to clone this tumor suppressor gene, our group is the first to map 
      the MEN1 region physically using yeast artificial chromosome, bacterial 
      artificial chromosome (BAC), and cosmid contigs. The 1.5-Mb high-resolution, 
      contiguous map extends from PYGM to 300 kb telomeric of D11S460. Of this, the 
      1.2-Mb interval between PYGM and D11S460 is isolated in cosmids and BACs and will 
      be useful for the development of genomic sequences and transcription maps of this 
      important region. Nine new sequence-tagged sites (STS) are also characterized 
      from this region. The physical map and the STSs will be valuable tools for the 
      cloning of the MEN1 gene.
FAU - Wood, T F
AU  - Wood TF
AD  - Department of Surgery (W112), VAMC West Los Angeles, UCLA School of Medicine 
      90073, USA.
FAU - Srivatsan, E S
AU  - Srivatsan ES
FAU - Chakrabarti, R
AU  - Chakrabarti R
FAU - Ma, G C
AU  - Ma GC
FAU - Kuan, N
AU  - Kuan N
FAU - Samara, G J
AU  - Samara GJ
FAU - Higgins, M J
AU  - Higgins MJ
FAU - Shows, T B
AU  - Shows TB
FAU - Johnson, C L
AU  - Johnson CL
FAU - Wan, Y J
AU  - Wan YJ
FAU - Passaro, E P Jr
AU  - Passaro EP Jr
FAU - Sawicki, M P
AU  - Sawicki MP
LA  - eng
GR  - HG00359/HG/NHGRI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Genomics
JT  - Genomics
JID - 8800135
SB  - IM
EIN - Genomics 1997 May 15;42(1):183
MH  - Chromosome Mapping
MH  - Chromosomes, Artificial, Yeast
MH  - Chromosomes, Bacterial
MH  - *Chromosomes, Human, Pair 11
MH  - Cosmids
MH  - Humans
MH  - Multiple Endocrine Neoplasia Type 1/*genetics
MH  - Sequence Tagged Sites
EDAT- 1996/12/01 00:00
MHDA- 2001/03/28 10:01
CRDT- 1996/12/01 00:00
PHST- 1996/12/01 00:00 [pubmed]
PHST- 2001/03/28 10:01 [medline]
PHST- 1996/12/01 00:00 [entrez]
AID - S0888754396906126 [pii]
AID - 10.1006/geno.1996.0612 [doi]
PST - ppublish
SO  - Genomics. 1996 Dec 1;38(2):166-73. doi: 10.1006/geno.1996.0612.