PMID- 8956297
OWN - NLM
STAT- MEDLINE
DCOM- 19970227
LR  - 20180215
IS  - 1660-8151 (Print)
IS  - 1660-8151 (Linking)
VI  - 74
IP  - 4
DP  - 1996
TI  - Platelet-derived growth factor, interleukin (IL)-1 beta, IL-6R and tumor necrosis 
      factor-alpha in IgA nephropathy. An immunohistochemical study.
PG  - 652-60
AB  - We clarified the presence of platelet-derived growth factor (PDGF), interleukin 
      (IL)-1 beta, IL-6, IL-6 receptor (IL-6R) and tumor necrosis factor-alpha 
      (TNF-alpha) in renal biopsy specimens from 62 patients with IgA nephropathy, and 
      discuss their relationship with mesangial cell proliferation, degree of 
      histological damage and various clinical factors. Mesangial proliferation was 
      determined histologically by PAS staining and the positive rate of proliferating 
      cell nuclear antigen (PCNA). Renal biopsy specimens were stained using an 
      enzyme-antibody method to determine the presence of cytokines and the receptor. 
      PCNA-positive cells in the glomeruli significantly increased in patients positive 
      for PDGF, IL-6, IL-6R and TNF-alpha. The degree of histological damage increased 
      with the positive rates of PDGF, IL-6 or IL-6R and the number of PCNA-positive 
      cells in the glomeruli. In the PDGF-A-positive patients, total urinary protein 
      (TUP), urinary beta2-microglobulin (u-beta2-m) and systolic and diastolic blood 
      pressure were significantly higher, and creatinine clearance (Ccr) was 
      significantly lower than in the PDGF-A-negative patients. In the PDGF-B-positive 
      patients, TUP, serum creatinine (s-Cr) and urinary and serum beta2-m increased 
      significantly and Ccr decreased significantly. Il-1beta was not related to any 
      clinical factors. In the IL-6-positive patients, TUP was significantly higher 
      than in the IL-6-negative patients. In the IL-6R-positive patients, TUP, s-Cr, 
      urinary beta2-m and systolic blood pressure were significantly higher than in the 
      IL-6R-negative patients. In conclusion, PDGF, IL-6 and IL-6R may be closely 
      related to mesangial cell proliferation, histological changes and deterioration 
      of various clinical factors in patients with IgA nephropathy.
FAU - Taniguchi, Y
AU  - Taniguchi Y
AD  - Second Department of Internal Medicine, Hiroshima University School of Medicine, 
      Japan.
FAU - Yorioka, N
AU  - Yorioka N
FAU - Oda, H
AU  - Oda H
FAU - Yamakido, M
AU  - Yamakido M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Switzerland
TA  - Nephron
JT  - Nephron
JID - 0331777
RN  - 0 (Antigens, CD)
RN  - 0 (Interleukin-1)
RN  - 0 (Interleukin-6)
RN  - 0 (Platelet-Derived Growth Factor)
RN  - 0 (Receptors, Interleukin)
RN  - 0 (Receptors, Interleukin-6)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Antigens, CD/*analysis
MH  - Female
MH  - Glomerulonephritis, IGA/*metabolism
MH  - Humans
MH  - Immunohistochemistry
MH  - Interleukin-1/*analysis
MH  - Interleukin-6/*analysis
MH  - Male
MH  - Middle Aged
MH  - Platelet-Derived Growth Factor/*analysis
MH  - Receptors, Interleukin/*analysis
MH  - Receptors, Interleukin-6
MH  - Tumor Necrosis Factor-alpha/*analysis
EDAT- 1996/01/01 00:00
MHDA- 1996/01/01 00:01
CRDT- 1996/01/01 00:00
PHST- 1996/01/01 00:00 [pubmed]
PHST- 1996/01/01 00:01 [medline]
PHST- 1996/01/01 00:00 [entrez]
AID - 10.1159/000189470 [doi]
PST - ppublish
SO  - Nephron. 1996;74(4):652-60. doi: 10.1159/000189470.