PMID- 8956498
OWN - NLM
STAT- MEDLINE
DCOM- 19970123
LR  - 20191210
VI  - 179
IP  - 6
DP  - 1996 Dec
TI  - A role for GABAergic inhibition in electrosensory processing and common mode 
      rejection in the dorsal nucleus of the little skate, Raja erinacea.
PG  - 797-807
AB  - The electrosensory primary afferents in elasmobranchs are responsive to electric 
      potentials created by the animal's own ventilation, while the second-order 
      neurons (AENs) which receive this afferent input in the medulla suppress 
      responses to ventilatory potentials but retain their extreme sensitivity to 
      electric signals in the environment. Ventilatory potentials are common mode 
      signals in elasmobranchs and a common mode rejection mechanism is one way the 
      AENs suppress ventilatory noise. By pressure injecting the GABA-A receptor 
      antagonist SR95531 while extracellularly recording from AENs, we tested the 
      hypothesis that the subtractive circuitry that selectively reduces common mode 
      signals in AENs utilizes GABA, and that a GABAergic component of the dorsal 
      nucleus commissural pathway mediates crossed inhibition of AENs. Local 
      application of SR95531 increased the spontaneous activity and the responsiveness 
      of AENs to electrosensory stimuli. AEN responses to a common mode stimulus were 
      selectively increased compared to responses to a localized stimulus due to 
      SR95531 application. Contralateral inhibition of AENs was blocked by SR95531, 
      indicating that GABAergic commissural cells may inhibit AENs when the 
      contralateral side of the body is stimulated, as with common mode stimulation. We 
      conclude that GABAergic inhibition contributes significantly to the shaping of 
      AEN responses including common mode rejection.
FAU - Duman, C H
AU  - Duman CH
AD  - Department of Biology, Shanklin Laboratory, Wesleyan University, Middletown, CT 
      06459-0170, USA.
FAU - Bodznick, D
AU  - Bodznick D
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - Germany
TA  - J Comp Physiol A
JT  - Journal of comparative physiology. A, Sensory, neural, and behavioral physiology
JID - 8413199
RN  - 0 (GABA Antagonists)
RN  - 0 (Glycine Agents)
RN  - 0 (Pyridazines)
RN  - 56-12-2 (gamma-Aminobutyric Acid)
RN  - 99460MG420 (gabazine)
RN  - H9Y79VD43J (Strychnine)
SB  - IM
MH  - Adaptation, Physiological
MH  - Animals
MH  - Brain/drug effects/*physiology
MH  - Calibration
MH  - Electric Stimulation
MH  - Electrophysiology
MH  - GABA Antagonists/pharmacology
MH  - Glycine Agents/pharmacology
MH  - Nerve Net/drug effects/physiology
MH  - Pyridazines/pharmacology
MH  - Sensation/drug effects/*physiology
MH  - Skates, Fish/*physiology
MH  - Strychnine/pharmacology
MH  - gamma-Aminobutyric Acid/*physiology
EDAT- 1996/12/01 00:00
MHDA- 1996/12/01 00:01
CRDT- 1996/12/01 00:00
PHST- 1996/12/01 00:00 [pubmed]
PHST- 1996/12/01 00:01 [medline]
PHST- 1996/12/01 00:00 [entrez]
AID - 10.1007/BF00207358 [doi]
PST - ppublish
SO  - J Comp Physiol A. 1996 Dec;179(6):797-807. doi: 10.1007/BF00207358.