PMID- 8956647
OWN - NLM
STAT- MEDLINE
DCOM- 19961231
LR  - 20190627
IS  - 0002-9394 (Print)
IS  - 0002-9394 (Linking)
VI  - 122
IP  - 6
DP  - 1996 Dec
TI  - Vogt-Koyanagi-Harada disease and HLA type in Italian patients.
PG  - 889-91
AB  - PURPOSE: To study the frequencies of human leukocyte antigen (HLA) specificities 
      in Italian patients with Vogt-Koyanagi-Harada disease and to correlate the 
      presence of each specificity to the clinical features. METHODS: Human leukocyte 
      antigen specificities were determined by standard microlymphocytotoxicity assay 
      in 16 patients with Vogt-Koyanagi-Harada disease and compared with HLA 
      specificities of 116 healthy controls. RESULTS: HLA-DR4 was statistically related 
      to Vogt-Koyanagi-Harada disease (P = .0063), whereas only a trend toward a 
      significant association between the disease and HLA-B41 was found (P = .06). 
      HLA-DQ1 was detected in a disproportionate number of controls (68.9%) compared 
      with patients (37.5%). CONCLUSIONS: HLA-DR4 was significantly related to 
      Vogt-Koyanagi-Harada disease in Caucasian European patients, specifically in 
      Italian patients, as it was described in other racial groups. No clear relation 
      was found between the ophthalmologic and systemic manifestations of 
      Vogt-Koyanagi-Harada disease and the presence of HLA specificities.
FAU - Pivetti-Pezzi, P
AU  - Pivetti-Pezzi P
AD  - Ocular Immunovirology Service, University of Rome La Sapienza, Italy.
FAU - Accorinti, M
AU  - Accorinti M
FAU - Colabelli-Gisoldi, R A
AU  - Colabelli-Gisoldi RA
FAU - Pirraglia, M P
AU  - Pirraglia MP
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Am J Ophthalmol
JT  - American journal of ophthalmology
JID - 0370500
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (Histocompatibility Antigens Class II)
SB  - IM
MH  - Adult
MH  - Female
MH  - Histocompatibility Antigens Class I/*immunology
MH  - Histocompatibility Antigens Class II/*immunology
MH  - Histocompatibility Testing
MH  - Humans
MH  - Italy
MH  - Male
MH  - Uveomeningoencephalitic Syndrome/*immunology
EDAT- 1996/12/01 00:00
MHDA- 1996/12/01 00:01
CRDT- 1996/12/01 00:00
PHST- 1996/12/01 00:00 [pubmed]
PHST- 1996/12/01 00:01 [medline]
PHST- 1996/12/01 00:00 [entrez]
AID - S0002-9394(14)70389-7 [pii]
AID - 10.1016/s0002-9394(14)70389-7 [doi]
PST - ppublish
SO  - Am J Ophthalmol. 1996 Dec;122(6):889-91. doi: 10.1016/s0002-9394(14)70389-7.