PMID- 8956873
OWN - NLM
STAT- MEDLINE
DCOM- 19961230
LR  - 20190816
IS  - 0165-4608 (Print)
IS  - 0165-4608 (Linking)
VI  - 92
IP  - 1
DP  - 1996 Nov
TI  - Acute promyelocytic leukemia with t(15;16;17;19) and unusual fluorescence in situ 
      hybridization pattern with PML and RARA probes.
PG  - 54-7
AB  - We report a 58-year-old female with typical morphological and clinical features 
      of acute promyelocytic leukemia in whom a complex translocation involving 
      chromosomes 15, 16, 17 and 19 was detected using conventional cytogenetics and 
      fluorescence in situ hybridization (FISH) with chromosome specific paints. 
      RARA-PML fusion was not evident by FISH, but the RARA signal was split in 74.5% 
      of cells. GTL-banding and FISH with probes for PML, RARA and chromosome 15 
      specific paint raise the possibility of PML-RARA fusion on the abnormal 
      chromosome 19 in the complex translocation. The unusual PML-RARA fusion may be 
      related to this patient's poor response to induction therapy with 
      all-trans-retinoic acid.
FAU - Kamal, N R
AU  - Kamal NR
AD  - Pathology Department, King Hussein Medical Center, Amman, Jordan.
FAU - Hanson, C A
AU  - Hanson CA
FAU - Dewald, G W
AU  - Dewald GW
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Cancer Genet Cytogenet
JT  - Cancer genetics and cytogenetics
JID - 7909240
RN  - 0 (DNA Probes)
RN  - 0 (Neoplasm Proteins)
RN  - 0 (Receptors, Retinoic Acid)
SB  - IM
MH  - *Chromosomes, Human, Pair 15
MH  - *Chromosomes, Human, Pair 16
MH  - *Chromosomes, Human, Pair 17
MH  - *Chromosomes, Human, Pair 19
MH  - DNA Probes
MH  - Female
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Leukemia, Promyelocytic, Acute/drug therapy/*genetics
MH  - Middle Aged
MH  - Neoplasm Proteins/*analysis/genetics
MH  - Receptors, Retinoic Acid/genetics
MH  - Translocation, Genetic/*genetics
EDAT- 1996/11/01 00:00
MHDA- 1996/11/01 00:01
CRDT- 1996/11/01 00:00
PHST- 1996/11/01 00:00 [pubmed]
PHST- 1996/11/01 00:01 [medline]
PHST- 1996/11/01 00:00 [entrez]
AID - S0165460896001331 [pii]
AID - 10.1016/s0165-4608(96)00133-1 [doi]
PST - ppublish
SO  - Cancer Genet Cytogenet. 1996 Nov;92(1):54-7. doi: 10.1016/s0165-4608(96)00133-1.