PMID- 8959490
OWN - NLM
STAT- MEDLINE
DCOM- 19970306
LR  - 20131121
IS  - 1061-186X (Print)
IS  - 1026-7158 (Linking)
VI  - 4
IP  - 3
DP  - 1996
TI  - Encapsulation of vancomycin and gentamicin within cationic liposomes for 
      inhibition of growth of Staphylococcus epidermidis.
PG  - 181-9
AB  - Liposomes have been prepared from dipalmitoylphosphatidylcholine (DPPC), 
      cholesterol (Chol) and dimethyldioctadecylammonium bromide (DDAB). The cationic 
      vesicles adsorb to biofilms of the skin-associated bacteria Staphylococcus 
      epidermidis, which have a negative charge. Encapsulation of the antibacterial 
      drug vancomycin into such liposomes enhanced its activity relative to the free 
      agent. The effectiveness of the preparation was dependent on the fluidity of the 
      liposomal membrane and on the level of drug entrapment within the aqueous core of 
      the vesicles. The aminoglycoside antibiotic gentamicin was also encapsulated 
      within similar liposomes but was less effective, possibly due to its slow passage 
      through the membrane. The liposomal vancomycin preparation has potential medical 
      use in treating bacterial infections of foreign body biomedical devices (e.g. 
      catheters), with either topical or intravenous administration.
FAU - Sanderson, N M
AU  - Sanderson NM
AD  - School of Biological Sciences, University of Manchester, UK.
FAU - Jones, M N
AU  - Jones MN
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Drug Target
JT  - Journal of drug targeting
JID - 9312476
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Drug Carriers)
RN  - 0 (Gentamicins)
RN  - 0 (Liposomes)
RN  - 6Q205EH1VU (Vancomycin)
SB  - IM
MH  - Anti-Bacterial Agents/*administration & dosage
MH  - Drug Carriers
MH  - Gentamicins/*administration & dosage
MH  - Liposomes
MH  - Staphylococcus epidermidis/*drug effects/growth & development
MH  - Vancomycin/*administration & dosage
EDAT- 1996/01/01 00:00
MHDA- 1996/01/01 00:01
CRDT- 1996/01/01 00:00
PHST- 1996/01/01 00:00 [pubmed]
PHST- 1996/01/01 00:01 [medline]
PHST- 1996/01/01 00:00 [entrez]
AID - 10.3109/10611869609015975 [doi]
PST - ppublish
SO  - J Drug Target. 1996;4(3):181-9. doi: 10.3109/10611869609015975.