PMID- 8960264
OWN - NLM
STAT- MEDLINE
DCOM- 19970124
LR  - 20131121
IS  - 0001-6837 (Print)
IS  - 0001-6837 (Linking)
VI  - 52
IP  - 6
DP  - 1995 Nov-Dec
TI  - Inclusion complexes of nifedipine and other 1.4-dihydropyridine derivatives with 
      cyclodextrins. IV. The UV study on photochemical stability of the inclusion 
      complexes of nisoldipine, nimodipine, nitrendipine and nicardipine with 
      beta-cyclodextrin in the solution.
PG  - 459-63
AB  - The results of measurements of photochemical stability of the inclusion complexes 
      formed by nimodipine (NM), nisoldipine (NS), nitrendipine (NR) and nicardipine 
      (NC) with beta-cyclodextrin (beta-CD) are reported. The inclusion complexes were 
      obtained in solution. The formation of inclusion complexes in the liquid phase 
      was estimated from a phase solubility diagram. The analysis of solubility curves 
      in the phase diagram permitted calculation of stability constants of the 
      inclusion complexes formed. Photochemical stability of 1.4-dihydropyridine 
      derivatives obeyed the 1 order kinetic equation. The photodegradation of NM, NR 
      and NC was found to be a single stage reaction. The photodegradation of NS 
      occurred in two stages. In the inclusion complexes the photosensitivity of all 
      studied DHP derivatives decreases. The complexation with beta-CD improved their 
      photostability by 5-10 times. The greatest decrease in the photodegradation rate 
      was observed for the most photosensitive compound NS whose photostability 
      increased 100 times when in inclusion complex with beta-CD.
FAU - Mielcarek, J
AU  - Mielcarek J
AD  - Department of Inorganic and Analytical Chemistry, K. Marcinkowski University of 
      Medical Sciences, Poznan, Poland.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - Poland
TA  - Acta Pol Pharm
JT  - Acta poloniae pharmaceutica
JID - 2985167R
RN  - 0 (Calcium Channel Blockers)
RN  - 0 (Cyclodextrins)
RN  - 0 (beta-Cyclodextrins)
RN  - 4I8HAB65SZ (Nisoldipine)
RN  - 57WA9QZ5WH (Nimodipine)
RN  - 9B627AW319 (Nitrendipine)
RN  - CZ5312222S (Nicardipine)
RN  - JV039JZZ3A (betadex)
SB  - IM
MH  - Calcium Channel Blockers/*chemistry
MH  - Cyclodextrins/*chemistry
MH  - Drug Stability
MH  - Nicardipine/*chemistry
MH  - Nimodipine/*chemistry
MH  - Nisoldipine/*chemistry
MH  - Nitrendipine/*chemistry
MH  - Photochemistry
MH  - *beta-Cyclodextrins
EDAT- 1995/11/01 00:00
MHDA- 1995/11/01 00:01
CRDT- 1995/11/01 00:00
PHST- 1995/11/01 00:00 [pubmed]
PHST- 1995/11/01 00:01 [medline]
PHST- 1995/11/01 00:00 [entrez]
PST - ppublish
SO  - Acta Pol Pharm. 1995 Nov-Dec;52(6):459-63.