PMID- 8960348
OWN - NLM
STAT- MEDLINE
DCOM- 19970304
LR  - 20211203
IS  - 0829-8211 (Print)
IS  - 0829-8211 (Linking)
VI  - 74
IP  - 4
DP  - 1996
TI  - Neuronal Cdc2-like kinase: from cell cycle to neuronal function.
PG  - 419-29
AB  - Neuronal Cdc2-like kinase, Nclk, is a heterodimer of cyclin-dependent protein 
      kinase 5 (Cdk5) and a 25-kDa essential regulatory subunit that is derived from a 
      35-kDa brain- and neuron-specific protein. This protein is called neuronal Cdk5 
      activator, p25/35nck5a. Nclk is one of the best characterized Cdc2 family kinases 
      whose primary function is not cell cycle related. It has been suggested that this 
      protein kinase plays important roles in neurocytoskeleton dynamics and its loss 
      of regulation has been implicated in Alzheimer pathology. As a member of the 
      Cdc2-like kinase family, Nclk shares many common properties with other members of 
      the Cdc2-like kinase family. It also possesses unique characteristics that may be 
      related to its distinct and noncell cycle related functions. The regulatory and 
      functional properties of Nclk are reviewed in this communication.
FAU - Tang, D
AU  - Tang D
AD  - Department of Biochemistry, Hong Kong University of Science and Technology, Clear 
      Water Bay, Kowloon, Hong Kong.
FAU - Lee, K Y
AU  - Lee KY
FAU - Qi, Z
AU  - Qi Z
FAU - Matsuura, I
AU  - Matsuura I
FAU - Wang, J H
AU  - Wang JH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - Canada
TA  - Biochem Cell Biol
JT  - Biochemistry and cell biology = Biochimie et biologie cellulaire
JID - 8606068
RN  - EC 2.7.11.1 (Cyclin-Dependent Kinase 5)
RN  - EC 2.7.11.1 (Protein Serine-Threonine Kinases)
RN  - EC 2.7.11.22 (CDK5 protein, human)
RN  - EC 2.7.11.22 (Cyclin-Dependent Kinases)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Brain/*enzymology
MH  - Cell Cycle
MH  - Cloning, Molecular
MH  - Cyclin-Dependent Kinase 5
MH  - *Cyclin-Dependent Kinases
MH  - Dimerization
MH  - Enzyme Activation
MH  - Humans
MH  - Molecular Sequence Data
MH  - Neurons/cytology/*enzymology
MH  - Protein Serine-Threonine Kinases/chemistry/genetics/*metabolism
MH  - Substrate Specificity
RF  - 56
EDAT- 1996/01/01 00:00
MHDA- 1996/01/01 00:01
CRDT- 1996/01/01 00:00
PHST- 1996/01/01 00:00 [pubmed]
PHST- 1996/01/01 00:01 [medline]
PHST- 1996/01/01 00:00 [entrez]
AID - 10.1139/o96-046 [doi]
PST - ppublish
SO  - Biochem Cell Biol. 1996;74(4):419-29. doi: 10.1139/o96-046.