PMID- 8962614
OWN - NLM
STAT- MEDLINE
DCOM- 19961204
LR  - 20051116
IS  - 0904-1850 (Print)
IS  - 0904-1850 (Linking)
VI  - 21
DP  - 1996 Apr
TI  - Immunological outcome measures.
PG  - 22s-27s
AB  - The determination of immunoglobulin E (IgE) antibodies by one of several 
      laboratory tests, by skin-prick tests or by appropriate challenge procedures is 
      useful either to identify atopic individuals or as outcome predictors in wheezy 
      children. The determination of allergen specific antibodies of other isotypes, 
      e.g. immunoglobulin G (IgG) and IgG subclass antibodies in serum, secretory 
      immunoglobulin A (IgA) and various immune complexes, have not been confirmed as 
      clinically useful tools for this purpose. Immune responses in atopic and 
      nonatopic individuals differ in several other respects, e.g. they express 
      somewhat different lymphocyte and cytokine profiles, as well as cellular immune 
      responses. At present, none of these differences can be employed clinically, 
      however, and the determinations are still research tools. A reduction in exposure 
      to allergens is associated with fewer symptoms and improved lung function in 
      sensitized individuals. There are also indications that reduced exposure to 
      allergens in early infancy may prevent, or at least delay, sensitization and 
      wheezing in atopic children. Determination of exposure to major indoor allergens, 
      e.g. house dust mite, cat and cockroach allergens, are, therefore, of value in 
      the assessment of the wheezing atopic infant. The relationship between wheezing 
      disorders and the results of most immunological tests remain to be defined. In 
      particular, the sensitivity, positive and negative predictive value and the 
      diagnostic efficiency of recently introduced immunoassays remain to be defined. 
      At present, there are no immunological tests of documented value to identify the 
      severity of disease, or to predict the outcome of a certain therapy.
FAU - Bjorksten, B
AU  - Bjorksten B
AD  - Dept of Pediatrics University Hospital, Linkoping Sweden.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Eur Respir J Suppl
JT  - The European respiratory journal. Supplement
JID - 8910681
RN  - 0 (Antibodies, Anti-Idiotypic)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Antibodies, Anti-Idiotypic/*analysis
MH  - *Asthma/immunology/physiopathology
MH  - Bronchial Hyperreactivity/diagnosis/*immunology
MH  - Bronchial Provocation Tests
MH  - Child, Preschool
MH  - Humans
MH  - Immunoglobulin E/*analysis
MH  - Infant
MH  - Patch Tests
MH  - Predictive Value of Tests
MH  - Respiratory Sounds/diagnosis/immunology
MH  - Sensitivity and Specificity
RF  - 26
EDAT- 1996/04/01 00:00
MHDA- 1996/04/01 00:01
CRDT- 1996/04/01 00:00
PHST- 1996/04/01 00:00 [pubmed]
PHST- 1996/04/01 00:01 [medline]
PHST- 1996/04/01 00:00 [entrez]
PST - ppublish
SO  - Eur Respir J Suppl. 1996 Apr;21:22s-27s.