PMID- 8962694
OWN - NLM
STAT- MEDLINE
DCOM- 19961217
LR  - 20061115
IS  - 0037-8771 (Print)
IS  - 0037-8771 (Linking)
VI  - 71
IP  - 9-10
DP  - 1995 Sep-Oct
TI  - Variations of the enzymatic activity of the rat's gum glycolytic cycle following 
      administration of sweeteners.
PG  - 249-56
AB  - The effects of saccharose and isomalt on the rat's gum carbohydrate metabolism 
      have been studied through evaluation of the activity of hexokinase (HK), 
      phosphoglucoisomerase (PGI), lactatedehydrogenase (LDH), 
      glucose-6-phosphate-dehydrogenase (G6PD), phosphofructokinase (PFK) and 
      phosphoglucomutase (PGM). The values obtained by administering a drink sweetened 
      with 10% isomalt are significantly lower (p < 0.05) than those obtained in the 
      animals that had the drink sweetened with 10% saccharose. Administration of the 
      same amount of drinks through gastric tube showed an enzymatic activity similar 
      to that of the rats in the control group. Intermediate metabolites of the 
      glycidic metabolism would then be responsible for the lesions of the oral 
      epithelium, as those obtained by administering high levels of vitamin A, through 
      an increased synthesis of acids. The increase of HK, PFK and PK activity with 
      respect to the control group in those rats that had the isomalt on the rat's gum 
      glycolytic cycle enzymes was found to be lower than that detected for other 
      polyalcohols.
FAU - Seri, S
AU  - Seri S
AD  - Institute of Nutrition, University of L'Aquila.
FAU - D'Alessandro, A
AU  - D'Alessandro A
FAU - Seri, M
AU  - Seri M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Italy
TA  - Boll Soc Ital Biol Sper
JT  - Bollettino della Societa italiana di biologia sperimentale
JID - 7506962
RN  - 0 (Disaccharides)
RN  - 0 (Enzymes)
RN  - 0 (Sugar Alcohols)
RN  - 57-50-1 (Sucrose)
RN  - 64519-82-0 (Palatinit)
SB  - IM
MH  - Animals
MH  - Disaccharides/*metabolism
MH  - Enzymes/*analysis
MH  - Gingiva/*metabolism
MH  - Glycolysis
MH  - Rats
MH  - Sucrose/*metabolism
MH  - Sugar Alcohols/*metabolism
EDAT- 1995/09/01 00:00
MHDA- 1995/09/01 00:01
CRDT- 1995/09/01 00:00
PHST- 1995/09/01 00:00 [pubmed]
PHST- 1995/09/01 00:01 [medline]
PHST- 1995/09/01 00:00 [entrez]
PST - ppublish
SO  - Boll Soc Ital Biol Sper. 1995 Sep-Oct;71(9-10):249-56.