PMID- 8964883
OWN - NLM
STAT- MEDLINE
DCOM- 19961211
LR  - 20041117
IS  - 0021-972X (Print)
IS  - 0021-972X (Linking)
VI  - 81
IP  - 6
DP  - 1996 Jun
TI  - Gs alpha mutation may be uncommon in patients with multiple endocrine neoplasia 
      type 1.
PG  - 2394-6
AB  - Activating mutations of the Gs alpha gene, termed gsp, have been identified in 
      various endocrine tumors. Recently, a high frequency of gsp mutation in patients 
      with multiple endocrinopathies was reported, and a family with both 
      McCune-Albright syndrome and multiple endocrine neoplasia type 1 was described. 
      Each suggests that the oncogenic mutations of Gs alpha may play an important role 
      in tumorigenesis in patients with multiple neoplastic endocrinopathies, and a 
      search for the gsp mutation in multiple endocrine neoplasia type 1 (MEN1) should 
      be undertaken. We, therefore, reevaluated the frequency of gsp mutations in 
      endocrine tumors of patients with MEN1. Of 18 tumors from 13 patients with MEN1, 
      we found no gsp mutations regardless of heredity. We conclude that the gsp 
      mutation may be uncommon in endocrine tumors of MEN1 patients, and thus, this 
      mutation plays little, if any, role in their tumorigenesis.
FAU - Sakurai, A
AU  - Sakurai A
AD  - Department of Geriatrics, Shinshu University School of Medicine, Matsumoto, 
      Japan.
FAU - Katai, M
AU  - Katai M
FAU - Furihata, K
AU  - Furihata K
FAU - Hashizume, K
AU  - Hashizume K
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Clin Endocrinol Metab
JT  - The Journal of clinical endocrinology and metabolism
JID - 0375362
RN  - 0 (Molecular Probes)
RN  - EC 3.6.1.- (GTP-Binding Proteins)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Base Sequence
MH  - Female
MH  - GTP-Binding Proteins/*genetics
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Molecular Probes/genetics
MH  - Molecular Sequence Data
MH  - Multiple Endocrine Neoplasia Type 1/*genetics
MH  - *Mutation
EDAT- 1996/06/01 00:00
MHDA- 1996/06/01 00:01
CRDT- 1996/06/01 00:00
PHST- 1996/06/01 00:00 [pubmed]
PHST- 1996/06/01 00:01 [medline]
PHST- 1996/06/01 00:00 [entrez]
AID - 10.1210/jcem.81.6.8964883 [doi]
PST - ppublish
SO  - J Clin Endocrinol Metab. 1996 Jun;81(6):2394-6. doi: 10.1210/jcem.81.6.8964883.