PMID- 8966350
OWN - NLM
STAT- MEDLINE
DCOM- 19961224
LR  - 20131121
IS  - 0034-9356 (Print)
IS  - 0034-9356 (Linking)
VI  - 43
IP  - 7
DP  - 1996 Aug-Sep
TI  - [Comparison of the double burst stimulus with the train-of-four stimuli in 
      monitoring muscle relaxation during anesthesia].
PG  - 235-8
AB  - OBJECTIVE: To compare double burst stimulus (DBS) and the train-of-four stimuli 
      (TOF) for monitoring neuromuscular blockade during anesthesia in terms of muscle 
      relaxation requirements, dose of anticholinesterase agents and the possibility of 
      postanesthetic residual relaxation. PATIENTS AND METHODS: Patients were randomly 
      assigned to two groups according to type of monitoring (DBS group, n = 29; and 
      TOF group, n = 28), and were given an adjusted infusion of vecuronium to obtain 
      response to stimulation with both methods of monitoring. When the block was 
      considered to be sufficiently reversed in the operating theater, the patients 
      were transferred to the postanesthesia recovery unit (PARU), where the 
      coefficient between the fourth and first responses to TOF (T4/T1r) was obtained 
      by electromyography and the patients were given the dose of neostigmine needed to 
      obtain a T4/T1r > 70% RESULTS: Vecuronium was infused at a faster rate during 
      anesthesia in the DBS group than in the TOF group (1.0 +/- 0.19 
      microgram.kg-1.min-1 and 0.8 +/- 0.24 microgram. kg-1.min-1, respectively, p = 
      0.005). T4/T1r was less than 70% upon arrival at the PARU in 10 DBS patients and 
      in 2 TOF patients (p = 0.02). No differences were found in neostigmine doses 
      given. CONCLUSIONS: The use of DBS increased the vecuronium dose required during 
      anesthesia and risk in those patients who arrived at the PARU with residual 
      muscle block (T4/T1r < 70%).
FAU - Gonzalez-Arevalo, A
AU  - Gonzalez-Arevalo A
AD  - Servicio de Anestesiologia, Hospital Universitatie, Getafe, Madrid.
FAU - Pensado, A
AU  - Pensado A
FAU - Caro, M M
AU  - Caro MM
FAU - Jimenez, J
AU  - Jimenez J
FAU - Jouve, M J
AU  - Jouve MJ
LA  - spa
PT  - Clinical Trial
PT  - English Abstract
PT  - Journal Article
PT  - Randomized Controlled Trial
TT  - Comparacion del estimulo a doble rafaga frente al tren de cuatro estimulos en la 
      monitorizacion de la relajacion muscular durante la anestesia.
PL  - Spain
TA  - Rev Esp Anestesiol Reanim
JT  - Revista espanola de anestesiologia y reanimacion
JID - 0134516
RN  - 0 (Neuromuscular Depolarizing Agents)
RN  - 7E4PHP5N1D (Vecuronium Bromide)
SB  - IM
MH  - Anesthesia Recovery Period
MH  - *Evoked Potentials, Somatosensory
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Monitoring, Intraoperative/*methods
MH  - *Nerve Block
MH  - *Neuromuscular Depolarizing Agents
MH  - Neuromuscular Junction/*drug effects/physiology
MH  - Prospective Studies
MH  - *Vecuronium Bromide
EDAT- 1996/08/01 00:00
MHDA- 1996/08/01 00:01
CRDT- 1996/08/01 00:00
PHST- 1996/08/01 00:00 [pubmed]
PHST- 1996/08/01 00:01 [medline]
PHST- 1996/08/01 00:00 [entrez]
PST - ppublish
SO  - Rev Esp Anestesiol Reanim. 1996 Aug-Sep;43(7):235-8.