PMID- 8967398
OWN - NLM
STAT- MEDLINE
DCOM- 19961204
LR  - 20180109
IS  - 0002-9513 (Print)
IS  - 0002-9513 (Linking)
VI  - 270
IP  - 4 Pt 2
DP  - 1996 Apr
TI  - Medullary sympathoexcitatory neurons are inhibited by activation of the medial 
      prefrontal cortex in the rat.
PG  - R713-9
AB  - Electrical stimulation of the medial prefrontal cortex (MPFC) reduces arterial 
      blood pressure. To investigate the mechanism of this response, the effects of 
      electrical and chemical stimulation of the MPFC on splanchnic and lumbar 
      sympathetic nerve discharge and on the discharges of barosensitive neurons of the 
      rostral ventrolateral medulla (RVLM) were studied in halothane-anesthetized rats. 
      Electrical stimulation (20 Hz, 1 ms, 100 and sympathoinhibitory responses 
      (reduced discharge of the splanchnic sympathetic nerve). Microinjection of 
      glutamate (10 nmol/100 nl) into the MPFC also reduced arterial blood pressure and 
      sympathetic discharge. Electrical stimulation (0.5 Hz, 1-ms pulse pairs, 3-ms 
      interval, 150-300 microA) produced distinct patterns of splanchnic and lumbar 
      sympathetic nerve discharge. A clear sympathoinhibitory phase with an onset 
      latency of 146 +/- 14 ms was observed only in the case of the splanchnic 
      sympathetic nerve activity. Electrical stimulation at depressor sites within the 
      MPFC also inhibited the discharge of 10 of 21 RVLM barosensitive neurons tested. 
      RVLM neurons were never excited by MPFC stimulation. These results indicate that 
      the MPFC contains neurons that form part of a central sympathoinhibitory pathway.
FAU - Verberne, A J
AU  - Verberne AJ
AD  - University of Melbourne, Clinical Pharmacology and Therapeutics Unit, Austin 
      Hospital, Heidelberg, Victoria, Australia.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Am J Physiol
JT  - The American journal of physiology
JID - 0370511
SB  - IM
MH  - Animals
MH  - Blood Pressure/physiology
MH  - Electric Stimulation
MH  - Male
MH  - Medulla Oblongata/cytology/*physiology
MH  - Motor Neurons/physiology
MH  - *Neural Inhibition
MH  - Neurons/*physiology
MH  - Prefrontal Cortex/*physiology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Sympathetic Nervous System/cytology/*physiology
MH  - Vasomotor System/physiology
EDAT- 1996/04/01 00:00
MHDA- 1996/04/01 00:01
CRDT- 1996/04/01 00:00
PHST- 1996/04/01 00:00 [pubmed]
PHST- 1996/04/01 00:01 [medline]
PHST- 1996/04/01 00:00 [entrez]
AID - 10.1152/ajpregu.1996.270.4.R713 [doi]
PST - ppublish
SO  - Am J Physiol. 1996 Apr;270(4 Pt 2):R713-9. doi: 10.1152/ajpregu.1996.270.4.R713.