PMID- 8968305
OWN - NLM
STAT- MEDLINE
DCOM- 19970113
LR  - 20190830
IS  - 0160-6689 (Print)
IS  - 0160-6689 (Linking)
VI  - 57
IP  - 11
DP  - 1996 Nov
TI  - Superiority of lithium over verapamil in mania: a randomized, controlled, 
      single-blind trial.
PG  - 543-6
AB  - BACKGROUND: Both case reports and small controlled studies suggest the efficacy 
      of verapamil in the treatment of mania. METHOD: Forty patients with DSM-IV mania 
      were studied in a 28-day randomized, controlled, single-blind trial of either 
      lithium or verapamil. RESULTS: The patients receiving lithium showed a 
      significant improvement on all rating scales (Brief Psychiatric Rating Scale 
      [BPRS], Mania Rating Scale [MRS], Global Assessment of Functioning [GAF], and 
      Clinical Global Impression [CGI]) compared with those receiving verapamil. The 
      mean MRS score at Day 28 in the lithium group was significantly lower than that 
      in the verapamil group (17.47 vs. 24.43, respectively; F = 6.17, df = 1, p = 
      .018). A similar pattern was seen with the BPRS (12.68 vs. 20.57; F = 10.69, df = 
      1, p = .002), CGI (2.31 vs. 3.33; F = 6.05, df = 1, p = .019), and GAF (43.52 vs. 
      52.31; F = 4.36, df = 1, p = .044) (ANCOVA). CONCLUSION: This study suggests that 
      lithium is superior to verapamil in the management of acute mania.
FAU - Walton, S A
AU  - Walton SA
AD  - Department of Psychiatry, University of the Witwatersrand Medical School, 
      Johannesburg, South Africa.
FAU - Berk, M
AU  - Berk M
FAU - Brook, S
AU  - Brook S
LA  - eng
PT  - Clinical Trial
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Clin Psychiatry
JT  - The Journal of clinical psychiatry
JID - 7801243
RN  - 0 (Placebos)
RN  - 2BMD2GNA4V (Lithium Carbonate)
RN  - CJ0O37KU29 (Verapamil)
SB  - IM
MH  - Acute Disease
MH  - Adolescent
MH  - Adult
MH  - Bipolar Disorder/diagnosis/*drug therapy/psychology
MH  - Female
MH  - Hospitalization
MH  - Hospitals, Psychiatric
MH  - Humans
MH  - Infant, Newborn
MH  - Lithium Carbonate/*therapeutic use
MH  - Male
MH  - Middle Aged
MH  - Placebos
MH  - Psychiatric Status Rating Scales
MH  - Severity of Illness Index
MH  - Single-Blind Method
MH  - Treatment Outcome
MH  - Verapamil/*therapeutic use
EDAT- 1996/11/01 00:00
MHDA- 1996/11/01 00:01
CRDT- 1996/11/01 00:00
PHST- 1996/11/01 00:00 [pubmed]
PHST- 1996/11/01 00:01 [medline]
PHST- 1996/11/01 00:00 [entrez]
AID - 10.4088/jcp.v57n1108 [doi]
PST - ppublish
SO  - J Clin Psychiatry. 1996 Nov;57(11):543-6. doi: 10.4088/jcp.v57n1108.