PMID- 8969918
OWN - NLM
STAT- MEDLINE
DCOM- 19970313
LR  - 20191024
IS  - 0743-5800 (Print)
IS  - 0743-5800 (Linking)
VI  - 22
IP  - 4
DP  - 1996 Nov
TI  - Effects of ecstasy on aldosterone secretion in the rat in vivo and in vitro.
PG  - 601-6
AB  - This study investigated the effects of Methylenedioxymethamphetamine (MDMA) on 
      aldosterone and renin secretion via, (1) acute administration of MDMA to 
      conscious Wistar rats, and (2) superfusion of whole rat adrenal capsules with 1 
      microM and 10 microM MDMA, in the presence of 5-HT. In study 1 basal aldosterone 
      levels increased significantly from 3.490 +/- 1.1 nmol/l to 12.099 +/- 2 nmol/l 
      after administration of MDMA (P < 0.05). Control rats showed no significant 
      increase in aldosterone secretion. Basal plasma renin activity (PRA) was 6.86 +/- 
      1.65 ng/ml/hr in the MDMA treated animals increasing to 228.56 +/- 34.1 ng/ml/hr 
      after administration (P < 0.05). In study 2 the aldosterone response to 5-HT was 
      potentiated by 1 microM and 10 microM MDMA. No consistent stimulation of 
      aldosterone was observed by MDMA alone. In conclusion, acute administration of 
      MDMA to conscious rats causes activation of the renin-angiotensin-aldosterone 
      system. In addition, MDMA can potentiate the direct action of 5-HT on aldosterone 
      secretion in vitro by a mechanism which could be associated with the 5-HT 
      transporter.
FAU - Burns, N
AU  - Burns N
AD  - Department of Medicine, Western General Hospital, Edinburgh.
FAU - Olverman, H J
AU  - Olverman HJ
FAU - Kelly, P A
AU  - Kelly PA
FAU - Williams, B C
AU  - Williams BC
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Endocr Res
JT  - Endocrine research
JID - 8408548
RN  - 4964P6T9RB (Aldosterone)
RN  - EC 3.4.23.15 (Renin)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Adrenal Glands/*drug effects/metabolism
MH  - Aldosterone/*metabolism
MH  - Animals
MH  - Female
MH  - In Vitro Techniques
MH  - N-Methyl-3,4-methylenedioxyamphetamine/administration & dosage/*pharmacology
MH  - Rats
MH  - Rats, Wistar
MH  - Renin/metabolism
EDAT- 1996/11/01 00:00
MHDA- 1996/11/01 00:01
CRDT- 1996/11/01 00:00
PHST- 1996/11/01 00:00 [pubmed]
PHST- 1996/11/01 00:01 [medline]
PHST- 1996/11/01 00:00 [entrez]
AID - 10.1080/07435809609043753 [doi]
PST - ppublish
SO  - Endocr Res. 1996 Nov;22(4):601-6. doi: 10.1080/07435809609043753.