PMID- 8970026
OWN - NLM
STAT- MEDLINE
DCOM- 19970310
LR  - 20220210
IS  - 1081-597X (Print)
IS  - 1081-597X (Linking)
VI  - 12
IP  - 7
DP  - 1996 Nov-Dec
TI  - Diclofenac and ketorolac in the treatment of pain after photorefractive 
      keratectomy.
PG  - 792-4
AB  - BACKGROUND: Photorefractive keratectomy (PRK) can produce significant ocular 
      pain. Topical diclofenac, a non-steroidal anti-inflammatory drug (NSAID), is 
      effective in the reduction of this pain. This study compares a second NSAID, 
      ketorolac, to diclofenac. METHODS: This prospective matched-control study 
      involved 102 eyes of 102 patients. Prior to PRK, patients were randomly assigned 
      to receive ketorolac or diclofenac drops. At the first postoperative visit, a 
      standardized questionnaire was used to assess the patient's average and peak 
      levels of discomfort. In addition, the quantities of acetaminophen and codeine 
      consumed were recorded. RESULTS: The overall level of discomfort was 1.53 +/- 
      0.64 for diclofenac and 1.88 +/- 0.55 for ketorolac (scale: 0 to 4) (P = 0.004). 
      The diclofenac group reported a peak discomfort level of 2.0 +/- 0.75 and the 
      ketorolac group reported 2.3 +/- 0.62 (P > 0.05). The diclofenac group consumed 
      2000 +/- 1150 mg of acetaminophen and 92 +/- 54 mg of codeine whereas the 
      ketorolac group consumed 2150 +/- 940 of acetaminophen and 98 +/- 50 mg of 
      codeine (P > 0.05). CONCLUSIONS: The differences in levels of peak discomfort, 
      acetaminophen ingestion, and codeine ingestion, were not statistically 
      significant. As compared to ketorolac, diclofenac resulted in a statistically 
      significant lower mean overall discomfort.
FAU - Weinstock, V M
AU  - Weinstock VM
AD  - University of Toronto, Canada.
FAU - Weinstock, D J
AU  - Weinstock DJ
FAU - Weinstock, S J
AU  - Weinstock SJ
LA  - eng
PT  - Clinical Trial
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - United States
TA  - J Refract Surg
JT  - Journal of refractive surgery (Thorofare, N.J. : 1995)
JID - 9505927
RN  - 0 (Anti-Inflammatory Agents, Non-Steroidal)
RN  - 0 (Ophthalmic Solutions)
RN  - 144O8QL0L1 (Diclofenac)
RN  - D8K2JPN18B (Tolmetin)
RN  - YZI5105V0L (Ketorolac)
SB  - IM
MH  - Administration, Topical
MH  - Adult
MH  - Anti-Inflammatory Agents, Non-Steroidal/*administration & dosage
MH  - Case-Control Studies
MH  - Cornea/*surgery
MH  - Diclofenac/*administration & dosage
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Ketorolac
MH  - Lasers, Excimer
MH  - Male
MH  - Middle Aged
MH  - Myopia/surgery
MH  - Ophthalmic Solutions
MH  - Pain, Postoperative/*drug therapy/etiology
MH  - Photorefractive Keratectomy/*adverse effects
MH  - Prospective Studies
MH  - Surveys and Questionnaires
MH  - Tolmetin/administration & dosage/*analogs & derivatives
MH  - Treatment Outcome
EDAT- 1996/11/01 00:00
MHDA- 1996/11/01 00:01
CRDT- 1996/11/01 00:00
PHST- 1996/11/01 00:00 [pubmed]
PHST- 1996/11/01 00:01 [medline]
PHST- 1996/11/01 00:00 [entrez]
AID - 10.3928/1081-597X-19961101-11 [doi]
PST - ppublish
SO  - J Refract Surg. 1996 Nov-Dec;12(7):792-4. doi: 10.3928/1081-597X-19961101-11.