PMID- 8970726
OWN - NLM
STAT- MEDLINE
DCOM- 19970312
LR  - 20061115
IS  - 1081-0706 (Print)
IS  - 1081-0706 (Linking)
VI  - 12
DP  - 1996
TI  - Fc receptors and their interactions with immunoglobulins.
PG  - 181-220
AB  - Receptors for the Fc domain of immunoglobulins play an important role in immune 
      defense. There are two well-defined functional classes of mammalian receptors. 
      One class of receptors transports immunoglobulins across epithelial tissues to 
      their main sites of action. This class includes the neonatal Fc receptor (FcRn), 
      which transports immunoglobulin G (IgG), and the polymeric immunoglobulin 
      receptor (pIgR), which transports immunoglobulin A (IgA) and immunoglobulin M 
      (IgM). Another class of receptors present on the surfaces of effector cells 
      triggers various biological responses upon binding antibody-antigen complexes. Of 
      these, the IgG receptors (Fc gamma R) and immunoglobulin E (IgE) receptors (Fc 
      epsilon R) are the best characterized. The biological responses elicited include 
      antibody-dependent, cell-mediated cytotoxicity, phagocytosis, release of 
      inflammatory mediators, and regulation of lymphocyte proliferation and 
      differentiation. We summarize the current knowledge of the structures and 
      functions of FcRn, pIgR, and the Fc gamma R and Fc epsilon RI proteins, 
      concentrating on the interactions of the extracellular portions of these 
      receptors with immunoglobulins.
FAU - Raghavan, M
AU  - Raghavan M
AD  - Division of Biology, Howard Hughes Medical Institute, California Institute of 
      Technology, Pasadena 91125, USA.
FAU - Bjorkman, P J
AU  - Bjorkman PJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Annu Rev Cell Dev Biol
JT  - Annual review of cell and developmental biology
JID - 9600627
RN  - 0 (Immunoglobulins)
RN  - 0 (Receptors, Fc)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Humans
MH  - Immunoglobulins/*physiology
MH  - Molecular Sequence Data
MH  - Receptors, Fc/*physiology
MH  - *Signal Transduction
RF  - 158
EDAT- 1996/01/01 00:00
MHDA- 1996/01/01 00:01
CRDT- 1996/01/01 00:00
PHST- 1996/01/01 00:00 [pubmed]
PHST- 1996/01/01 00:01 [medline]
PHST- 1996/01/01 00:00 [entrez]
AID - 10.1146/annurev.cellbio.12.1.181 [doi]
PST - ppublish
SO  - Annu Rev Cell Dev Biol. 1996;12:181-220. doi: 10.1146/annurev.cellbio.12.1.181.