PMID- 8971816
OWN - NLM
STAT- MEDLINE
DCOM- 19970320
LR  - 20190701
IS  - 0304-3940 (Print)
IS  - 0304-3940 (Linking)
VI  - 219
IP  - 3
DP  - 1996 Nov 29
TI  - Immunohistochemical investigation of human leukocyte antigen (HLA)-DR-positive 
      astrocytes in adrenoleukodystrophy brain.
PG  - 207-10
AB  - We investigated immunohistochemically the expression of human leukocyte antigen 
      (HLA)-DR in postmortem brain tissue of two adult patients with 
      adrenoleukodystrophy (ALD). In addition to microglia and macrophages, a 
      significant number of star-like cells were stained positively for HLA-DR in 
      demyelinating lesions of both patients. Such cells congregated in the peripheral 
      zone of the lesions. A mirror image analysis as well as double immunostaining for 
      HLA-DR and glial fibrillary acidic protein established that these cells were a 
      subset of reactive astrocytes. Together with other reports demonstrating that 
      astrocytes express HLA-DR only under very limited conditions, the results of this 
      study suggest the involvement of immune and inflammatory responses in the 
      pathological processes of ALD.
FAU - Katsuragi, T
AU  - Katsuragi T
AD  - Department of Psychiatry, Yokohama City University School of Medicine, Japan.
FAU - Iseki, E
AU  - Iseki E
FAU - Kosaka, K
AU  - Kosaka K
FAU - Nishimura, T
AU  - Nishimura T
FAU - Akiyama, H
AU  - Akiyama H
FAU - Ikeda, K
AU  - Ikeda K
FAU - Kato, M
AU  - Kato M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (Glial Fibrillary Acidic Protein)
RN  - 0 (HLA-DR Antigens)
SB  - IM
MH  - Adrenoleukodystrophy/*immunology/metabolism/pathology
MH  - Adult
MH  - Astrocytes/*immunology/metabolism
MH  - Brain/*immunology/metabolism/pathology
MH  - Demyelinating Diseases/immunology/metabolism/pathology
MH  - Glial Fibrillary Acidic Protein/metabolism
MH  - HLA-DR Antigens/*analysis
MH  - Humans
MH  - Immunohistochemistry
MH  - Middle Aged
EDAT- 1996/11/29 00:00
MHDA- 1996/11/29 00:01
CRDT- 1996/11/29 00:00
PHST- 1996/11/29 00:00 [pubmed]
PHST- 1996/11/29 00:01 [medline]
PHST- 1996/11/29 00:00 [entrez]
AID - S0304394096132158 [pii]
AID - 10.1016/s0304-3940(96)13215-8 [doi]
PST - ppublish
SO  - Neurosci Lett. 1996 Nov 29;219(3):207-10. doi: 10.1016/s0304-3940(96)13215-8.