PMID- 8972179
OWN - NLM
STAT- MEDLINE
DCOM- 19970122
LR  - 20220318
IS  - 0270-7306 (Print)
IS  - 1098-5549 (Electronic)
IS  - 0270-7306 (Linking)
VI  - 17
IP  - 1
DP  - 1997 Jan
TI  - The mammalian transcriptional repressor RBP (CBF1) regulates interleukin-6 gene 
      expression.
PG  - 1-9
AB  - The cellular interleukin-6 (IL-6) gene contains a target site for the mammalian 
      transcriptional repressor RBP. The target site is contained within the 
      interleukin response element (ILRE), which mediates IL-6 activation by NF-kappa 
      B. In this study, we show by using transient-expression assays that RBP represses 
      activated transcription from the IL-6 gene. The presence and position of the RBP 
      target site are crucial in mediating repression by RBP. While RBP binds within 
      the ILRE, it does not target NF-kappa B alone; nonetheless, NF-kappa B binding to 
      the ILRE is required for repression. Our results indicate that RBP represses 
      coactivation by NF-kappa B and another cellular transcription factor, C/EBP-beta.
FAU - Kannabiran, C
AU  - Kannabiran C
AD  - Department of Biochemistry, Robert Wood Johnson Medical School, University of 
      Medicine and Dentistry of New Jersey, Piscataway 08854-5635, USA.
FAU - Zeng, X
AU  - Zeng X
FAU - Vales, L D
AU  - Vales LD
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - United States
TA  - Mol Cell Biol
JT  - Molecular and cellular biology
JID - 8109087
RN  - 0 (CCAAT-Enhancer-Binding Proteins)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Immunoglobulin J Recombination Signal Sequence-Binding Protein)
RN  - 0 (Interleukin-6)
RN  - 0 (Interleukins)
RN  - 0 (NF-kappa B)
RN  - 0 (Nuclear Proteins)
RN  - 0 (RNA, Messenger)
RN  - 0 (Rbpj protein, mouse)
RN  - 0 (Repressor Proteins)
RN  - 0 (Transcription Factor RelA)
SB  - IM
MH  - 3T3 Cells
MH  - Animals
MH  - Binding Sites
MH  - CCAAT-Enhancer-Binding Proteins
MH  - COS Cells
MH  - Cell Line
MH  - DNA-Binding Proteins/genetics/*metabolism/pharmacology
MH  - Gene Expression Regulation/*physiology
MH  - Immunoglobulin J Recombination Signal Sequence-Binding Protein
MH  - Interleukin-6/*genetics
MH  - Interleukins
MH  - Mice
MH  - Mutation
MH  - NF-kappa B/pharmacology
MH  - Nuclear Proteins/pharmacology
MH  - Promoter Regions, Genetic/genetics
MH  - RNA, Messenger/biosynthesis
MH  - Repressor Proteins/genetics/*metabolism
MH  - Transcription Factor RelA
MH  - Transcription, Genetic/genetics
MH  - Transcriptional Activation/drug effects
PMC - PMC231723
EDAT- 1997/01/01 00:00
MHDA- 1997/01/01 00:01
PMCR- 1997/01/01
CRDT- 1997/01/01 00:00
PHST- 1997/01/01 00:00 [pubmed]
PHST- 1997/01/01 00:01 [medline]
PHST- 1997/01/01 00:00 [entrez]
PHST- 1997/01/01 00:00 [pmc-release]
AID - 10.1128/MCB.17.1.1 [doi]
PST - ppublish
SO  - Mol Cell Biol. 1997 Jan;17(1):1-9. doi: 10.1128/MCB.17.1.1.