PMID- 8972783
OWN - NLM
STAT- MEDLINE
DCOM- 19970320
LR  - 20161018
IS  - 0892-7790 (Print)
IS  - 0892-7790 (Linking)
VI  - 10
IP  - 6
DP  - 1996 Dec
TI  - Stone recurrence after shockwave lithotripsy: possible enhanced crystal 
      deposition in traumatized tissue in rabbit model.
PG  - 513-7
AB  - To evaluate the possible traumatizing effect of high-energy shockwaves (HESW) on 
      new stone formation as indicated by crystal deposition in the renal parenchyma, 
      we performed an experimental study in 50 rabbits. During severe oxaluria induced 
      by continuous ethylene glycol (0.75%) administration, animals in the first group 
      (N = 15) received 500 to 1500 shockwaves. Animals in the second group (N = 15) 
      underwent no specific therapy apart from ethylene glycol administration. In a 
      third group of animals (N = 15), only shockwave administration was applied. Sham 
      group animals constituted the last group in our study (N = 5). Three months after 
      shockwave application, tissue sections obtained from treated and untreated 
      kidneys were evaluated histopathologically under light and transmission electron 
      microscopy (TEM) for the presence and degree of crystal deposition in the 
      cortical parenchymal region subjected to HESW. Crystal deposition was evident in 
      the intercellular region and intratubular parts of the parenchyma in animals 
      subjected to HESW application, especially in those receiving relatively high 
      (1000 or 1500) numbers of shockwaves. On the other hand, no crystal formation and 
      deposition was detectable in animals undergoing only ethylene glycol therapy or 
      shockwave administration alone. Sham group animals demonstrated no significant 
      renal histopathology. The traumatic effects of HESW should be evaluated as a 
      factor in new stone formation after SWL.
FAU - Sarica, K
AU  - Sarica K
AD  - Department of Urology, University of Ankara Medical School, Ibn-i Sina Hospital, 
      Turkey.
FAU - Soygur, T
AU  - Soygur T
FAU - Yaman, O
AU  - Yaman O
FAU - Ozer, G
AU  - Ozer G
FAU - Sayin, N
AU  - Sayin N
FAU - Akbay, C
AU  - Akbay C
FAU - Kupeli, S
AU  - Kupeli S
FAU - Yaman, L S
AU  - Yaman LS
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Endourol
JT  - Journal of endourology
JID - 8807503
RN  - 0 (Ethylene Glycols)
RN  - 0 (Oxalates)
RN  - FC72KVT52F (Ethylene Glycol)
SB  - IM
MH  - Animals
MH  - Crystallization
MH  - Disease Models, Animal
MH  - Ethylene Glycol
MH  - Ethylene Glycols/toxicity
MH  - High-Energy Shock Waves/*adverse effects
MH  - Kidney/drug effects/*radiation effects/ultrastructure
MH  - Kidney Calculi/*etiology/metabolism/pathology
MH  - Microscopy, Electron
MH  - Oxalates/metabolism/*radiation effects
MH  - Prospective Studies
MH  - Rabbits
MH  - Recurrence
EDAT- 1996/12/01 00:00
MHDA- 1996/12/01 00:01
CRDT- 1996/12/01 00:00
PHST- 1996/12/01 00:00 [pubmed]
PHST- 1996/12/01 00:01 [medline]
PHST- 1996/12/01 00:00 [entrez]
AID - 10.1089/end.1996.10.513 [doi]
PST - ppublish
SO  - J Endourol. 1996 Dec;10(6):513-7. doi: 10.1089/end.1996.10.513.