PMID- 8974396
OWN - NLM
STAT- MEDLINE
DCOM- 19970117
LR  - 20191210
IS  - 0036-8075 (Print)
IS  - 0036-8075 (Linking)
VI  - 275
IP  - 5296
DP  - 1997 Jan 3
TI  - The inverse association between tuberculin responses and atopic disorder.
PG  - 77-9
AB  - Human immune responses are heterogeneous and may involve antagonism between T 
      helper (TH) lymphocyte subsets and their cytokines. Atopy is characterized by 
      immediate immunoglobulin E (IgE)-mediated hypersensitivity to agents such as dust 
      mites and pollen, and it underlies the increasingly prevalent disorder asthma. 
      Among Japanese schoolchildren, there was a strong inverse association between 
      delayed hypersensitivity to Mycobacterium tuberculosis and atopy. Positive 
      tuberculin responses predicted a lower incidence of asthma, lower serum IgE 
      levels, and cytokine profiles biased toward TH1 type. Exposure and response to M. 
      tuberculosis may, by modification of immune profiles, inhibit atopic disorder.
FAU - Shirakawa, T
AU  - Shirakawa T
AD  - Lung Research Laboratory, Osler Chest Unit, Churchill Hospital, Oxford OX3 7LJ, 
      UK. jhopkin@immsvr.jr2.ox.ac.uk
FAU - Enomoto, T
AU  - Enomoto T
FAU - Shimazu, S
AU  - Shimazu S
FAU - Hopkin, J M
AU  - Hopkin JM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Science
JT  - Science (New York, N.Y.)
JID - 0404511
RN  - 0 (BCG Vaccine)
RN  - 0 (Cytokines)
RN  - 0 (Tuberculin)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 82115-62-6 (Interferon-gamma)
SB  - IM
CIN - Science. 1997 Jan 3;275(5296):41-2. PMID: 8999535
CIN - Science. 1997 Apr 4;276(5309):17; author reply 18-9. PMID: 9122695
CIN - Science. 1997 Apr 4;276(5309):17-8; author reply 18-9. PMID: 9122696
MH  - Adolescent
MH  - Asthma/epidemiology/etiology/immunology
MH  - BCG Vaccine/immunology
MH  - Child
MH  - Confounding Factors, Epidemiologic
MH  - Cytokines/blood
MH  - Female
MH  - Humans
MH  - Hypersensitivity, Delayed/*immunology
MH  - Hypersensitivity, Immediate/epidemiology/*etiology/immunology
MH  - Immunoglobulin E/blood
MH  - Interferon-gamma/blood
MH  - Japan/epidemiology
MH  - Male
MH  - Th1 Cells/immunology
MH  - Th2 Cells/immunology
MH  - Tuberculin/*immunology
MH  - Tuberculin Test
MH  - Tuberculosis/*epidemiology/immunology
EDAT- 1997/01/03 00:00
MHDA- 1997/01/03 00:01
CRDT- 1997/01/03 00:00
PHST- 1997/01/03 00:00 [pubmed]
PHST- 1997/01/03 00:01 [medline]
PHST- 1997/01/03 00:00 [entrez]
AID - 10.1126/science.275.5296.77 [doi]
PST - ppublish
SO  - Science. 1997 Jan 3;275(5296):77-9. doi: 10.1126/science.275.5296.77.