PMID- 8974790
OWN - NLM
STAT- MEDLINE
DCOM- 19970102
LR  - 20191101
IS  - 1269-3286 (Print)
IS  - 1269-3286 (Linking)
VI  - 38
IP  - 3
DP  - 1996 Jul
TI  - Childhood B-cell acute lymphoblastic leukemia with FAB-L1 morphology and a 
      t(9;11) translocation involving the MLL gene.
PG  - 265-8
AB  - The t(9;11) (p21-22;q23) translocation is frequently associated with acute 
      monoblastic leukemia but may occasionally be seen in patients with acute 
      lymphoblastic leukemia (ALL). We report a case of childhood ALL associated with 
      t(9;11) (p21-22;q23) as the unique recurring chromosomal abnormality. A 
      3-month-old girl presented with "lymphomatous" ALL (renal enlargement), a high 
      leukocyte count and central nervous system (CNS) involvement. Leukemic cell 
      typing revealed a sIg+ B-cell immunophenotype without CD10 and CD34 antigenic 
      expression while the blast cell morphology was of the FAB-L1 type. Splitting of a 
      YAC encompassing the MLL gene was shown by fluorescence in situ hybridization 
      (FISH) studies of the patient's metaphase chromosomes. Rearrangement of the MLL 
      gene was confirmed by Southern blot analysis. Despite treatment with an 
      hyperintensive polychemotherapeutic regimen, the patient achieved a complete 
      remission but relapsed 9 months later. These results provide further evidence 
      that the t(9;11) may be observed in ALL, involves the MLL gene and is associated 
      with a poor outcome. Moreover, this observation clearly illustrates that sIg+ 
      B-cell ALL is not necessarily associated with a Burkitt (L3) morphology.
FAU - Talmant, P
AU  - Talmant P
AD  - Unite de Cytogenetique Hematologique, Institut de Biologie, Nantes, France.
FAU - Berger, R
AU  - Berger R
FAU - Robillard, N
AU  - Robillard N
FAU - Mechineau-Lacroix, F
AU  - Mechineau-Lacroix F
FAU - Garand, R
AU  - Garand R
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - France
TA  - Hematol Cell Ther
JT  - Hematology and cell therapy
JID - 9613253
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Immunoglobulin Fab Fragments)
RN  - 0 (KMT2A protein, human)
RN  - 0 (Transcription Factors)
RN  - 149025-06-9 (Myeloid-Lymphoid Leukemia Protein)
RN  - EC 2.1.1.43 (Histone-Lysine N-Methyltransferase)
SB  - IM
MH  - B-Lymphocytes/immunology
MH  - *Chromosomes, Human, Pair 11
MH  - *Chromosomes, Human, Pair 9
MH  - DNA-Binding Proteins/*genetics
MH  - Female
MH  - Histone-Lysine N-Methyltransferase
MH  - Humans
MH  - Immunoglobulin Fab Fragments
MH  - Infant
MH  - Myeloid-Lymphoid Leukemia Protein
MH  - Precursor Cell Lymphoblastic Leukemia-Lymphoma/*genetics/immunology
MH  - *Proto-Oncogenes
MH  - *Transcription Factors
MH  - *Translocation, Genetic
EDAT- 1996/07/01 00:00
MHDA- 1996/07/01 00:01
CRDT- 1996/07/01 00:00
PHST- 1996/07/01 00:00 [pubmed]
PHST- 1996/07/01 00:01 [medline]
PHST- 1996/07/01 00:00 [entrez]
AID - 10.1007/s00282-996-0265-8 [doi]
PST - ppublish
SO  - Hematol Cell Ther. 1996 Jul;38(3):265-8. doi: 10.1007/s00282-996-0265-8.