PMID- 8976014
OWN - NLM
STAT- MEDLINE
DCOM- 19970319
LR  - 20221207
IS  - 0036-5521 (Print)
IS  - 0036-5521 (Linking)
VI  - 31
IP  - 12
DP  - 1996 Dec
TI  - Relationship between human leukocyte antigen determinants and courses of 
      hepatitis B virus infection in Caucasian patients with end-stage renal disease.
PG  - 1211-5
AB  - BACKGROUND: Divergent results have been reported with regard to the relationship 
      between the course of hepatitis B virus (HBV) infection and the human leukocyte 
      antigen (HLA) determinants. The aim of the present study was to investigate the 
      phenotype frequencies of HLA class-I and -II alleles in Caucasians with and 
      without HBV infection. METHODS: Fifty-eight patients with persistent HBV 
      infection (group 1), 119 patients with resolved HBV infection (group 2), and 106 
      patients neither infected by HBV nor vaccinated against HBV (group 3) were 
      analyzed. All patients had end-stage renal disease. HLA class-I antigens were 
      serologically determined. For HLA class-II typing we performed DRB1, DQA1, and 
      DQB1 genotyping using a polymerase chain reaction-sequence-specific 
      oligonucleotide procedure. RESULTS: Compared with group 2, group 1 showed 
      increased frequencies of HLA-B8, DR3 (P < 0.05), A30, DQA1*0501 (P < 0.01), and a 
      decreased frequency of HLA-B12 (P < 0.05). Decreased frequencies of HLA-B27, B40, 
      DR13, and DQ1*0604 (P < 0.05) and an increased frequency of HLA-B35 (P < 0.05) 
      were found in groups 1 and 2 compared with controls (group 3). None of the 
      differences detected in the phenotype frequencies of HLA alleles were 
      statistically significant after correction. CONCLUSIONS: We conclude that the 
      susceptibility to HBV infection and the different courses of HBV infection are 
      not strongly related to HLA status in Caucasians.
FAU - Chen, D F
AU  - Chen DF
AD  - Dept. of Nephrology, Medical University of Hanover, Germany.
FAU - Kliem, V
AU  - Kliem V
FAU - Endres, W
AU  - Endres W
FAU - Brunkhorst, R
AU  - Brunkhorst R
FAU - Tillmann, H L
AU  - Tillmann HL
FAU - Koch, K M
AU  - Koch KM
FAU - Manns, M P
AU  - Manns MP
FAU - Stangel, W
AU  - Stangel W
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - England
TA  - Scand J Gastroenterol
JT  - Scandinavian journal of gastroenterology
JID - 0060105
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Alleles
MH  - Chi-Square Distribution
MH  - Female
MH  - HLA Antigens/*analysis/blood
MH  - Hepatitis B/complications/*immunology
MH  - Humans
MH  - Kidney Failure, Chronic/complications/*immunology
MH  - Male
MH  - Middle Aged
MH  - Reference Values
MH  - *White People
EDAT- 1996/12/01 00:00
MHDA- 1996/12/01 00:01
CRDT- 1996/12/01 00:00
PHST- 1996/12/01 00:00 [pubmed]
PHST- 1996/12/01 00:01 [medline]
PHST- 1996/12/01 00:00 [entrez]
AID - 10.3109/00365529609036912 [doi]
PST - ppublish
SO  - Scand J Gastroenterol. 1996 Dec;31(12):1211-5. doi: 10.3109/00365529609036912.