PMID- 8976366
OWN - NLM
STAT- MEDLINE
DCOM- 19970122
LR  - 20190816
IS  - 0165-4608 (Print)
IS  - 0165-4608 (Linking)
VI  - 92
IP  - 2
DP  - 1996 Dec
TI  - Dicentric (9;20)(p11;q11) identified by fluorescence in situ hybridization in 
      four pediatric acute lymphoblastic leukemia patients.
PG  - 111-5
AB  - Four children with acute lymphocytic leukemia (ALL) and a dic(9;20) are 
      described. All four patients were diagnosed with pre-B-cell All, and the three 
      for whom information was available were CD10+. Age at diagnosis ranged from 23 
      months to 12 years. All patients achieved remission, with two in continuous 
      remission for 2 years 6 months and 3 years, one patient relapsed, dying 3 years 2 
      months after diagnosis, and one patient was lost to follow-up. These four 
      patients were initially diagnosed as having a deletion of 9p and loss of one 
      chromosome 20. Re-examination of the karyotypes indicated a possible dic(9;20). 
      The dicentric chromosome was verified using dual-color fluorescence in situ 
      hybridization (FISH) with centromeric probes for chromosomes 9 and 20 on 
      interphase nuclei. Three of the four patients had multiple chromosomal 
      abnormalities in addition to the translocation; one was hypodiploid, one was 
      pseudodiploid, and two were hyperdiploid. This dicentric chromosome was recently 
      described in four adult and nine pediatric patients with ALL [8, 9]. All reported 
      patients had CD10+ pre-B-cell All, and achieved remission, as was the case for 
      our four pediatric dic(9;20) patients. Two of our three patients for whom 
      follow-up is available are in continuous remission as were two adults and five 
      pediatric patients in the previous reports. These studies confirm the dic(9;20) 
      as a recurring abnormality in ALL. Due to the subtle nature of the translocation, 
      FISH is very useful in confirming the chromosomal abnormality.
FAU - Heerema, N A
AU  - Heerema NA
AD  - Department of Medical and Molecular Genetics, Indiana University School of 
      Medicine, Indianapolis 46202-5251, USA.
FAU - Maben, K D
AU  - Maben KD
FAU - Bernstein, J
AU  - Bernstein J
FAU - Breitfeld, P P
AU  - Breitfeld PP
FAU - Neiman, R S
AU  - Neiman RS
FAU - Vance, G H
AU  - Vance GH
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Cancer Genet Cytogenet
JT  - Cancer genetics and cytogenetics
JID - 7909240
SB  - IM
MH  - Adult
MH  - Bone Marrow/pathology
MH  - Burkitt Lymphoma/*genetics/mortality/pathology/therapy
MH  - Centromere/pathology
MH  - Child
MH  - Child, Preschool
MH  - *Chromosome Aberrations
MH  - Chromosome Deletion
MH  - *Chromosome Disorders
MH  - Chromosome Mapping
MH  - *Chromosomes, Human, Pair 20
MH  - *Chromosomes, Human, Pair 9
MH  - Follow-Up Studies
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Infant
MH  - Interphase
MH  - Karyotyping
MH  - Precursor B-Cell Lymphoblastic 
      Leukemia-Lymphoma/*genetics/mortality/pathology/therapy
MH  - Time Factors
MH  - *Translocation, Genetic
EDAT- 1996/12/01 00:00
MHDA- 1996/12/01 00:01
CRDT- 1996/12/01 00:00
PHST- 1996/12/01 00:00 [pubmed]
PHST- 1996/12/01 00:01 [medline]
PHST- 1996/12/01 00:00 [entrez]
AID - S0165460896001720 [pii]
AID - 10.1016/s0165-4608(96)00172-0 [doi]
PST - ppublish
SO  - Cancer Genet Cytogenet. 1996 Dec;92(2):111-5. doi: 10.1016/s0165-4608(96)00172-0.