PMID- 8978020
OWN - NLM
STAT- MEDLINE
DCOM- 19970320
LR  - 20061115
IS  - 0882-8245 (Print)
IS  - 0882-8245 (Linking)
VI  - 9
IP  - 4
DP  - 1996
TI  - Varicella zoster virus-specific cytotoxicity following secondary immunization 
      with live or killed vaccine.
PG  - 241-5
AB  - Subjects > or = 55 years of age were immunized with attenuated varicella zoster 
      virus (VZV) vaccine (live) or with the same vaccine, which had been heated to 56 
      degrees C for 7 days (killed). The ability of subjects' blood lymphocytes to lyse 
      target cells infected with VZV was determined before and 3 months after 
      immunization using autologous Epstein-Barr virus (EBV) lymphoblasts as targets 
      for human leukocyte antigen (HLA) class I restricted cytotoxicity and human 
      fibroblasts as targets for unrestricted (natural killer [NK]) cytotoxicity. The 
      live vaccine recipients showed an increase in their class I-restricted lysis of 
      targets compared with the recipients of the killed vaccine. The two populations 
      showed equivalent increase in their NK-dependent lysis of fibroblast targets. The 
      results support the view that both the live and killed vaccines stimulate 
      cytotoxicity by VZV-specific lymphocytes but that the live vaccine stimulates 
      relatively more class I-restricted killing.
FAU - Hayward, A R
AU  - Hayward AR
AD  - Department of Pediatrics, University of Colorado School of Medicine, Denver, USA.
FAU - Buda, K
AU  - Buda K
FAU - Jones, M
AU  - Jones M
FAU - White, C J
AU  - White CJ
FAU - Levin, M J
AU  - Levin MJ
LA  - eng
PT  - Clinical Trial
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - United States
TA  - Viral Immunol
JT  - Viral immunology
JID - 8801552
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (Vaccines, Attenuated)
RN  - 0 (Vaccines, Inactivated)
RN  - 0 (Viral Envelope Proteins)
RN  - 0 (Viral Vaccines)
RN  - 0 (glycoprotein IV, varicella-zoster virus)
SB  - IM
MH  - Aged
MH  - B-Lymphocytes/cytology/*immunology
MH  - Cells, Cultured
MH  - Cytotoxicity Tests, Immunologic
MH  - Herpesvirus 3, Human/*immunology
MH  - Herpesvirus 4, Human/immunology
MH  - Histocompatibility Antigens Class I/*immunology
MH  - Humans
MH  - Immunization
MH  - Killer Cells, Natural/*immunology
MH  - Middle Aged
MH  - Vaccines, Attenuated/*immunology
MH  - Vaccines, Inactivated/*immunology
MH  - Viral Envelope Proteins/immunology
MH  - Viral Vaccines/*immunology
EDAT- 1996/01/01 00:00
MHDA- 1996/01/01 00:01
CRDT- 1996/01/01 00:00
PHST- 1996/01/01 00:00 [pubmed]
PHST- 1996/01/01 00:01 [medline]
PHST- 1996/01/01 00:00 [entrez]
AID - 10.1089/vim.1996.9.241 [doi]
PST - ppublish
SO  - Viral Immunol. 1996;9(4):241-5. doi: 10.1089/vim.1996.9.241.