PMID- 8978276
OWN - NLM
STAT- MEDLINE
DCOM- 19970127
LR  - 20210216
IS  - 0006-4971 (Print)
IS  - 0006-4971 (Linking)
VI  - 89
IP  - 1
DP  - 1997 Jan 1
TI  - Major histocompatibility complex restriction between hematopoietic stem cells and 
      stromal cells in vivo.
PG  - 49-54
AB  - Graft failure is a mortal complication in allogeneic bone marrow transplantation 
      (BMT); T cells and natural killer cells are responsible for graft rejection. 
      However, we have recently demonstrated that the recruitment of donor-derived 
      stromal cells prevents graft failure in allogeneic BMT. This finding prompted us 
      to examine whether a major histocompatibility complex (MHC) restriction exists 
      between hematopoietic stem cells (HSCs) and stromal cells. We transplanted bone 
      marrow cells (BMCs) and bones obtained from various mouse strains and analyzed 
      the cells that accumulated in the engrafted bones. Statistically significant cell 
      accumulation was found in the engrafted bone, which had the same H-2 phenotype as 
      that of the BMCs, whereas only few cells were detected in the engrafted bones of 
      the third-party H-2 phenotypes during the 4 to 6 weeks after BMT. Moreover, the 
      BMCs obtained from the MHC-compatible bone showed significant numbers of both 
      colony-forming units in culture (CFU-C) and spleen colony-forming units (CFU-S). 
      These findings strongly suggest that an MHC restriction exists between HSCs and 
      stromal cells.
FAU - Hashimoto, F
AU  - Hashimoto F
AD  - First Department of Pathology, Kansai Medical University, Osaka, Japan.
FAU - Sugiura, K
AU  - Sugiura K
FAU - Inoue, K
AU  - Inoue K
FAU - Ikehara, S
AU  - Ikehara S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Blood
JT  - Blood
JID - 7603509
RN  - 0 (H-2 Antigens)
RN  - 0 (Minor Lymphocyte Stimulatory Antigens)
SB  - IM
MH  - Animals
MH  - Bone Marrow/*immunology
MH  - Bone Marrow Cells
MH  - Bone Marrow Transplantation/*immunology
MH  - Bone Transplantation/*immunology
MH  - Cell Movement
MH  - Colony-Forming Units Assay
MH  - Connective Tissue/*immunology
MH  - Female
MH  - H-2 Antigens/*immunology
MH  - Hematopoietic Stem Cells/*immunology
MH  - Histocompatibility
MH  - Immunophenotyping
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Mice, Inbred C3H
MH  - Mice, Inbred C57BL
MH  - Mice, Inbred DBA
MH  - Minor Lymphocyte Stimulatory Antigens/immunology
MH  - Radiation Chimera
MH  - Transplantation, Homologous/immunology
EDAT- 1997/01/01 00:00
MHDA- 1997/01/01 00:01
CRDT- 1997/01/01 00:00
PHST- 1997/01/01 00:00 [pubmed]
PHST- 1997/01/01 00:01 [medline]
PHST- 1997/01/01 00:00 [entrez]
AID - S0006-4971(20)76781-9 [pii]
PST - ppublish
SO  - Blood. 1997 Jan 1;89(1):49-54.