PMID- 8980383
OWN - NLM
STAT- MEDLINE
DCOM- 19970127
LR  - 20220408
IS  - 0007-0920 (Print)
IS  - 1532-1827 (Electronic)
IS  - 0007-0920 (Linking)
VI  - 74
IP  - 12
DP  - 1996 Dec
TI  - Overexpression and activation of hepatocyte growth factor/scatter factor in human 
      non-small-cell lung carcinomas.
PG  - 1862-8
AB  - Hepatocyte growth factor/scatter factor (HGF/SF) stimulates the invasive growth 
      of epithelial cells via the c-MET oncogene-encoded receptor. In normal lung, both 
      the receptor and the ligand are detected, and the latter is known to be a 
      mitogenic and a motogenic factor for both cultured bronchial epithelial cells and 
      non-small-cell carcinoma lines. Here, ligand and receptor expression was examined 
      in 42 samples of primary human non-small-cell lung carcinoma of different 
      histotype. Each carcinoma sample was compared with adjacent normal lung tissue. 
      The Met/HGF receptor was found to be 2 to 10-fold increased in 25% of carcinoma 
      samples (P = 0.0113). The ligand, HGF/SF, was found to be 10 to 100-fold 
      overexpressed in carcinoma samples (P < 0.0001). Notably, while HGF/SF was 
      occasionally detectable and found exclusively as a single-chain inactive 
      precursor in normal tissues, it was constantly in the biologically-active 
      heterodimeric form in carcinomas. Immunohistochemical staining showed homogeneous 
      expression of both the receptor and the ligand in carcinoma samples, whereas 
      staining was barely detectable in their normal counterparts. These data show that 
      HGF/SF is overexpressed and consistently activated in non-small-cell lung 
      carcinomas and may contribute to the invasive growth of lung cancer.
FAU - Olivero, M
AU  - Olivero M
AD  - Institute for Cancer Research and Treatment IRCC, Torino, Italy.
FAU - Rizzo, M
AU  - Rizzo M
FAU - Madeddu, R
AU  - Madeddu R
FAU - Casadio, C
AU  - Casadio C
FAU - Pennacchietti, S
AU  - Pennacchietti S
FAU - Nicotra, M R
AU  - Nicotra MR
FAU - Prat, M
AU  - Prat M
FAU - Maggi, G
AU  - Maggi G
FAU - Arena, N
AU  - Arena N
FAU - Natali, P G
AU  - Natali PG
FAU - Comoglio, P M
AU  - Comoglio PM
FAU - Di Renzo, M F
AU  - Di Renzo MF
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Br J Cancer
JT  - British journal of cancer
JID - 0370635
RN  - 0 (Antibodies, Monoclonal)
RN  - 67256-21-7 (Hepatocyte Growth Factor)
RN  - EC 2.7.10.1 (Proto-Oncogene Proteins c-met)
RN  - EC 2.7.10.1 (Receptor Protein-Tyrosine Kinases)
SB  - IM
MH  - Adenocarcinoma/metabolism/pathology
MH  - Adult
MH  - Aged
MH  - Antibodies, Monoclonal/analysis
MH  - Blotting, Western/methods
MH  - Carcinoma, Non-Small-Cell Lung/*metabolism/pathology
MH  - Carcinoma, Squamous Cell/metabolism/pathology
MH  - Female
MH  - Hepatocyte Growth Factor/*biosynthesis
MH  - Humans
MH  - Lung/metabolism
MH  - Lung Neoplasms/*metabolism/pathology
MH  - Male
MH  - Middle Aged
MH  - Proto-Oncogene Proteins c-met
MH  - Receptor Protein-Tyrosine Kinases/*biosynthesis
PMC - PMC2074802
EDAT- 1996/12/01 00:00
MHDA- 1996/12/01 00:01
CRDT- 1996/12/01 00:00
PHST- 1996/12/01 00:00 [pubmed]
PHST- 1996/12/01 00:01 [medline]
PHST- 1996/12/01 00:00 [entrez]
AID - 10.1038/bjc.1996.646 [doi]
PST - ppublish
SO  - Br J Cancer. 1996 Dec;74(12):1862-8. doi: 10.1038/bjc.1996.646.