PMID- 8981595
OWN - NLM
STAT- MEDLINE
DCOM- 19970328
LR  - 20190712
IS  - 0091-3057 (Print)
IS  - 0091-3057 (Linking)
VI  - 55
IP  - 4
DP  - 1996 Dec
TI  - Developmental consequences of intermittent and continuous prenatal exposure to 
      1,1,1-trichloroethane in mice.
PG  - 635-46
AB  - The effects of 1,1,1-trichloroethane (TCE) on physical and behavioral development 
      were examined in CD-1 mice prenatally exposed under two regimens. In the first 
      study, pregnant mice were exposed to either 2,000 ppm TCE or filtered air for 17 
      hrs. during gestational days (GD) 12-17. A third group remained untreated. The 
      results revealed no differences on pregnancy outcome. TCE-exposed pups gained 
      less weight, exhibited delays in developmental landmarks and acquisition of the 
      righting reflex, had poorer performance on tests of motor coordination and 
      exhibited delays in negative geotaxis relative to sham or untreated pups. A 
      second experiment was designed to more closely parallel the intermittent, acute, 
      high-concentration pattern of solvent abuse. Pregnant mice were exposed for 60 
      min. to 8,000 ppm TCE or sham placement in exposure chambers three times/day 
      during GD's 12-17. The results were very similar to what were obtained in the 
      more continuous exposure study. TCE-exposed pups gained less weight, had delays 
      in developmental landmarks and acquisition of the righting reflex and exhibited 
      weaker grip strength, poorer negative geotaxis and less rooting intensity in 
      comparison to sham pups. These data provide evidence for the behavioral and 
      developmental teratogenicity of prenatal TCE exposure late in gestation.
FAU - Jones, H E
AU  - Jones HE
AD  - Department of Pharmacology and Toxicology, Medical College of Virginia, Virginia 
      Commonwealth University, Richmond 23298-0613, USA.
FAU - Kunko, P M
AU  - Kunko PM
FAU - Robinson, S E
AU  - Robinson SE
FAU - Balster, R L
AU  - Balster RL
LA  - eng
GR  - DA03112/DA/NIDA NIH HHS/United States
GR  - DA05665/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Pharmacol Biochem Behav
JT  - Pharmacology, biochemistry, and behavior
JID - 0367050
RN  - 0 (Solvents)
RN  - 0 (Trichloroethanes)
RN  - 113C650IR1 (1,1,1-trichloroethane)
SB  - IM
MH  - Animals
MH  - Avoidance Learning/drug effects
MH  - Body Weight/drug effects
MH  - Dose-Response Relationship, Drug
MH  - Female
MH  - Gestational Age
MH  - Male
MH  - Mice
MH  - Mice, Inbred Strains
MH  - Motor Activity/drug effects
MH  - Nervous System/drug effects/*growth & development
MH  - Postural Balance/drug effects
MH  - Pregnancy
MH  - *Prenatal Exposure Delayed Effects
MH  - Psychomotor Performance/drug effects
MH  - Reflex/drug effects
MH  - Solvents/administration & dosage/chemistry/*toxicity
MH  - Substance-Related Disorders/psychology
MH  - Trichloroethanes/administration & dosage/chemistry/*toxicity
EDAT- 1996/12/01 00:00
MHDA- 1996/12/01 00:01
CRDT- 1996/12/01 00:00
PHST- 1996/12/01 00:00 [pubmed]
PHST- 1996/12/01 00:01 [medline]
PHST- 1996/12/01 00:00 [entrez]
AID - S0091-3057(96)00288-2 [pii]
AID - 10.1016/s0091-3057(96)00288-2 [doi]
PST - ppublish
SO  - Pharmacol Biochem Behav. 1996 Dec;55(4):635-46. doi: 
      10.1016/s0091-3057(96)00288-2.