PMID- 8981781
OWN - NLM
STAT- MEDLINE
DCOM- 19970204
LR  - 20190909
IS  - 0301-486X (Print)
IS  - 0301-486X (Linking)
VI  - 134
IP  - 3
DP  - 1996
TI  - Developmental effects of fumonisin B1 in mice.
PG  - 161-6
AB  - Developmental and toxic effects of aqueous extracts of F. moniliforme culture 
      material containing known levels of fumonisin B1 were recently reported in mice 
      and included maternal hepatotoxicity and lethality, maternal body weight gain 
      reduction, increased embryonic resorptions, reduced offspring body weights, and 
      fetal malformations including cleft palate, hydrocephalus, malformed ribs and 
      incomplete digital and sternal ossification. These studies also suggested that 
      the effects of the fungal extract on the mouse offspring may be mediated via 
      maternal effects. The contribution of fumonisin B1 (FB1), a major toxic 
      metabolite of F. moniliforme, in the induction of these effects was evaluated in 
      this study by administering 0 to 100 mg pure FB1/kg of body weight on gestational 
      days (GD) 7 through 15 to pregnant Charles River CD1 mice and assessing maternal 
      health and fetal development till the end of gestation. Doses of 25 mg/kg or 
      higher of pure FB1 induced maternal liver lesions (mostly necrotic changes), 
      associated with ascites and increased hepatocytic nuclear diameter. Fumonisin 
      doses of 50 mg/kg or higher also resulted in significantly increased maternal ALT 
      on GD12, and reduced offspring bodyweights on GD18. Increased resorptions and 
      decreased numbers of live offspring were only evident at 100 mg FB1/kg body 
      weight. Offspring exhibited dose-dependent increase in the incidence and severity 
      of hydrocephalus of both the lateral and third ventricles at doses of 25 mg/kg or 
      higher. Doses of 25 mg/kg or higher also increased the sphinganine/sphingosine 
      (Sa/So) ratios in maternal but not fetal livers. These results suggest that FB1 
      may be a developmental toxicant accounting for most but not all earlier reported 
      effects of F. moniliforme culture extract. Association of FB1 effects on the 
      offspring with maternal hepatoxicity and with alteration of Sa/So ratio in 
      maternal but not fetal liver supported the earlier claim that FB1 effects on the 
      mouse offspring are mediated by maternal hepatotoxicity.
FAU - Reddy, R V
AU  - Reddy RV
AD  - Department of Veterinary Biomedical Sciences, University of Missouri, Columbia 
      65211, USA.
FAU - Johnson, G
AU  - Johnson G
FAU - Rottinghaus, G E
AU  - Rottinghaus GE
FAU - Casteel, S W
AU  - Casteel SW
FAU - Reddy, C S
AU  - Reddy CS
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Mycopathologia
JT  - Mycopathologia
JID - 7505689
RN  - 0 (Fumonisins)
RN  - 0 (Mycotoxins)
RN  - 3ZZM97XZ32 (fumonisin B1)
RN  - EC 2.6.1.2 (Alanine Transaminase)
RN  - NGZ37HRE42 (Sphingosine)
RN  - OWA98U788S (safingol)
SB  - IM
MH  - Alanine Transaminase/blood
MH  - Animals
MH  - Body Weight/drug effects
MH  - Embryonic and Fetal Development/*drug effects
MH  - Female
MH  - Fetal Resorption/chemically induced
MH  - *Fumonisins
MH  - Hydrocephalus/chemically induced
MH  - Litter Size/drug effects
MH  - Liver/chemistry/*drug effects/embryology
MH  - Mice
MH  - Mycotoxins/*toxicity
MH  - Pregnancy
MH  - Sphingosine/analogs & derivatives/analysis
EDAT- 1996/01/01 00:00
MHDA- 1996/01/01 00:01
CRDT- 1996/01/01 00:00
PHST- 1996/01/01 00:00 [pubmed]
PHST- 1996/01/01 00:01 [medline]
PHST- 1996/01/01 00:00 [entrez]
AID - 10.1007/BF00436724 [doi]
PST - ppublish
SO  - Mycopathologia. 1996;134(3):161-6. doi: 10.1007/BF00436724.