PMID- 8982104
OWN - NLM
STAT- MEDLINE
DCOM- 19970122
LR  - 20190826
IS  - 0165-5728 (Print)
IS  - 0165-5728 (Linking)
VI  - 71
IP  - 1-2
DP  - 1996 Dec
TI  - Tumor necrosis factor alpha and interleukin-6 mRNA expression in neonatal Lewis 
      rat Schwann cells and a neonatal rat Schwann cell line following interferon gamma 
      stimulation.
PG  - 65-71
AB  - There is increasing evidence that Schwann cells play an important role in the 
      pathogenesis of autoimmune inflammatory peripheral nerve disease. Schwann cells 
      have been reported to express major histocompatibility complex class I and II 
      (MHC I and II) and intercellular adhesion molecule-1 (ICAM-1), and to produce 
      interleukin-1 (IL-1), prostaglandin E2 and thromboxane A2. In this study we 
      investigated freshly dissociated neonatal Lewis rat Schwann cells and a SV40 
      transfected neonatal rat Schwann cell line (Schwann cell line) for production of 
      mRNA for the immunomodulatory cytokines IL-2, IL-4, IL-6, IL-10, interferon-gamma 
      (IFN gamma), and tumor necrosis factor-alpha (TNF alpha) employing RT-PCR. 
      Primary Schwann cells and Schwann cell line were examined following IFN gamma 
      stimulation and were found to express TNF alpha and IL-6 mRNA. These results 
      further support a role for Schwann cell participation in inflammatory responses 
      within the peripheral nervous system (PNS).
FAU - Murwani, R
AU  - Murwani R
AD  - Neuroscience Unit, School of Biological Sciences, University of Sydney, NSW, 
      Australia. ani@bio.usyd.edu.au
FAU - Hodgkinson, S
AU  - Hodgkinson S
FAU - Armati, P
AU  - Armati P
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - J Neuroimmunol
JT  - Journal of neuroimmunology
JID - 8109498
RN  - 0 (Interleukin-6)
RN  - 0 (RNA, Messenger)
RN  - 0 (Recombinant Proteins)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 130068-27-8 (Interleukin-10)
RN  - 207137-56-2 (Interleukin-4)
RN  - 82115-62-6 (Interferon-gamma)
SB  - IM
MH  - Animals
MH  - Animals, Newborn
MH  - Cell Line
MH  - Cell Transformation, Viral
MH  - Gene Expression
MH  - Interferon-gamma/*pharmacology
MH  - Interleukin-10/genetics
MH  - Interleukin-4/genetics
MH  - Interleukin-6/*genetics
MH  - RNA, Messenger/genetics
MH  - Rats
MH  - Rats, Inbred Lew
MH  - Recombinant Proteins
MH  - Schwann Cells/*metabolism
MH  - Simian virus 40
MH  - Tumor Necrosis Factor-alpha/*genetics
EDAT- 1996/12/01 00:00
MHDA- 2000/06/01 09:00
CRDT- 1996/12/01 00:00
PHST- 1996/12/01 00:00 [pubmed]
PHST- 2000/06/01 09:00 [medline]
PHST- 1996/12/01 00:00 [entrez]
AID - S0165-5728(96)00131-2 [pii]
AID - 10.1016/s0165-5728(96)00131-2 [doi]
PST - ppublish
SO  - J Neuroimmunol. 1996 Dec;71(1-2):65-71. doi: 10.1016/s0165-5728(96)00131-2.