PMID- 8982163
OWN - NLM
STAT- MEDLINE
DCOM- 19970127
LR  - 20220309
IS  - 0896-6273 (Print)
IS  - 0896-6273 (Linking)
VI  - 17
IP  - 6
DP  - 1996 Dec
TI  - Hepatocyte growth factor/scatter factor is an axonal chemoattractant and a 
      neurotrophic factor for spinal motor neurons.
PG  - 1157-72
AB  - In the embryonic nervous system, developing axons can be guided to their targets 
      by diffusible factors secreted by their intermediate and final cellular targets. 
      To date only one family of chemoattractants for developing axons has been 
      identified. Grafting and ablation experiments in fish, amphibians, and birds have 
      suggested that spinal motor axons are guided to their targets in the limb in part 
      by a succession of chemoattractants made by the sclerotome and by the limb 
      mesenchyme, two intermediate targets that these axons encounter en route to their 
      target muscles. Here we identify the limb mesenchyme-derived chemoattractant as 
      hepatocyte growth factor/scatter factor (HGF/SF), a diffusible ligand for the 
      c-Met receptor tyrosine kinase, and we also implicate HGF/SF at later stages as a 
      muscle-derived survival factor for motoneurons. These results indicate that, in 
      addition to functioning as a mitogen, a motogen, and a morphogen in nonneural 
      systems, HGF/SF can function as a guidance and survival factor in the developing 
      nervous system.
FAU - Ebens, A
AU  - Ebens A
AD  - Howard Hughes Medical Institute, Department of Anatomy, University of California, 
      San Francisco 94143-0452, USA.
FAU - Brose, K
AU  - Brose K
FAU - Leonardo, E D
AU  - Leonardo ED
FAU - Hanson, M G Jr
AU  - Hanson MG Jr
FAU - Bladt, F
AU  - Bladt F
FAU - Birchmeier, C
AU  - Birchmeier C
FAU - Barres, B A
AU  - Barres BA
FAU - Tessier-Lavigne, M
AU  - Tessier-Lavigne M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - United States
TA  - Neuron
JT  - Neuron
JID - 8809320
RN  - 0 (Chemotactic Factors)
RN  - 0 (Nerve Growth Factors)
RN  - 67256-21-7 (Hepatocyte Growth Factor)
SB  - IM
MH  - Animals
MH  - Axons/*physiology
MH  - Cell Survival/physiology
MH  - Cells, Cultured
MH  - Chemotactic Factors/*physiology
MH  - Extremities/embryology/innervation
MH  - Hepatocyte Growth Factor/*physiology
MH  - Motor Neurons/*physiology
MH  - Nerve Growth Factors/*physiology
MH  - Neural Pathways/physiology
MH  - Rats/embryology
MH  - Spinal Cord/cytology/embryology/*physiology
EDAT- 1996/12/01 00:00
MHDA- 2001/03/28 10:01
CRDT- 1996/12/01 00:00
PHST- 1996/12/01 00:00 [pubmed]
PHST- 2001/03/28 10:01 [medline]
PHST- 1996/12/01 00:00 [entrez]
AID - S0896-6273(00)80247-0 [pii]
AID - 10.1016/s0896-6273(00)80247-0 [doi]
PST - ppublish
SO  - Neuron. 1996 Dec;17(6):1157-72. doi: 10.1016/s0896-6273(00)80247-0.