PMID- 8982294
OWN - NLM
STAT- MEDLINE
DCOM- 19970122
LR  - 20190909
IS  - 0902-4441 (Print)
IS  - 0902-4441 (Linking)
VI  - 57
IP  - 4
DP  - 1996 Oct
TI  - Transfusion of platelet concentrates--clinical evaluation of two preparations.
PG  - 307-11
AB  - The aim of this study was to compare the clinical effect of transfusion of 
      platelet concentrates (PC) prepared from pooled buffy coats (BC) and PCs 
      collected from a single donor (SD) by an apheresis technique. The influence of 
      storage time and various clinical conditions was also studied. Thirty-two 
      patients suffering from haematological malignancies were given a total of 326 
      platelet concentrates; 180 BC-PCs and 146 SD-PCs, median 7 transfusions per 
      patient. BC-PCs contained 312 +/- 52 x 10(9) and SD-PCs 383 +/- 133 x 10(9) 
      platelets/unit (mean +/- SD). The mean storage time of BC-PC was 3 d and that of 
      SD-PC 1 d. The mean platelet count of the patients before transfusion was 11 +/- 
      8 x 10(9)/L. Regression analysis showed a significant decrease of the 
      post-transfusion platelet corrected count increment (CCI) during storage of PCs 
      for 1-5 d (BC-PC: p < 0.01; SD-PC: p < 0.05). There was no difference in platelet 
      increment between BC-PC and SD-PC. Human leukocyte antigen (HLA) alloimmunization 
      was the major cause of clinical refractoriness to random donor platelet 
      transfusions but splenomegaly also caused low CCI values.
FAU - Strindberg, J
AU  - Strindberg J
AD  - Department of Transfusion Medicine and Clinical Immunology, University Hospital, 
      Linkoping, Sweden.
FAU - Berlin, G
AU  - Berlin G
LA  - eng
PT  - Clinical Trial
PT  - Controlled Clinical Trial
PT  - Journal Article
PL  - England
TA  - Eur J Haematol
JT  - European journal of haematology
JID - 8703985
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Blood Coagulation
MH  - Blood Component Removal
MH  - Blood Preservation
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Humans
MH  - Infant
MH  - Male
MH  - Middle Aged
MH  - Platelet Count
MH  - Platelet Transfusion/*methods
MH  - Time Factors
EDAT- 1996/10/01 00:00
MHDA- 1996/10/01 00:01
CRDT- 1996/10/01 00:00
PHST- 1996/10/01 00:00 [pubmed]
PHST- 1996/10/01 00:01 [medline]
PHST- 1996/10/01 00:00 [entrez]
AID - 10.1111/j.1600-0609.1996.tb01382.x [doi]
PST - ppublish
SO  - Eur J Haematol. 1996 Oct;57(4):307-11. doi: 10.1111/j.1600-0609.1996.tb01382.x.