PMID- 8982535
OWN - NLM
STAT- MEDLINE
DCOM- 19970318
LR  - 20190909
IS  - 0305-4179 (Print)
IS  - 0305-4179 (Linking)
VI  - 22
IP  - 8
DP  - 1996 Dec
TI  - Plasma levels of endothelin-1 and thrombomodulin in burn patients.
PG  - 594-7
AB  - Plasma concentrations of endothelin-1 (ET-1) and thrombomodulin (TM) were 
      determined in patients with burns to examine their relation to the severity of 
      illness. Tumor necrosis factor-alpha (TNF-alpha) was also measured, and its 
      relationship to ET-1 and TM determined. Twenty-three burn patients were 
      evaluated, who had a total burn surface area (TBSA) of at least 20 per cent. ET-1 
      was measured by radioimmunoassay (RIA). TM and TNF-alpha were measured by 
      enzyme-linked immunosorbent assay (ELISA). Both the ET-1 and TM concentrations 
      were significantly higher in the patients who developed sepsis than in those who 
      did not and in the patients who eventually died than in those who survived. 
      Maximum plasma concentrations of ET-1 and TM were significantly correlated with 
      the acute physiological and chronic health evaluation II score. There was also a 
      significant correlation between the plasma levels of TNF-alpha and both ET-1 and 
      TM. ET-1 and TM closely reflect the severity of illness in patients with burns in 
      the infectious stage; TNF-alpha may be involved in the production of ET-1 and TM.
FAU - Nakae, H
AU  - Nakae H
AD  - Critical Care and Emergency Center, Iwate Medical University, Morioka, Japan.
FAU - Endo, S
AU  - Endo S
FAU - Inada, K
AU  - Inada K
FAU - Yamada, Y
AU  - Yamada Y
FAU - Takakuwa, T
AU  - Takakuwa T
FAU - Yoshida, M
AU  - Yoshida M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Burns
JT  - Burns : journal of the International Society for Burn Injuries
JID - 8913178
RN  - 0 (Endothelin-1)
RN  - 0 (Thrombomodulin)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - APACHE
MH  - Adult
MH  - Aged
MH  - Body Surface Area
MH  - Burns/*blood/classification/complications/pathology
MH  - Endothelin-1/biosynthesis/*blood
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Radioimmunoassay
MH  - Sepsis/blood/complications
MH  - Severity of Illness Index
MH  - Survival Rate
MH  - Thrombomodulin/biosynthesis/*blood
MH  - Tumor Necrosis Factor-alpha/analysis/physiology
MH  - Wound Infection/blood/complications
EDAT- 1996/12/01 00:00
MHDA- 1996/12/01 00:01
CRDT- 1996/12/01 00:00
PHST- 1996/12/01 00:00 [pubmed]
PHST- 1996/12/01 00:01 [medline]
PHST- 1996/12/01 00:00 [entrez]
AID - S0305417996000630 [pii]
AID - 10.1016/s0305-4179(96)00063-0 [doi]
PST - ppublish
SO  - Burns. 1996 Dec;22(8):594-7. doi: 10.1016/s0305-4179(96)00063-0.