PMID- 8982683
OWN - NLM
STAT- MEDLINE
DCOM- 19970612
LR  - 20190624
IS  - 0014-2999 (Print)
IS  - 0014-2999 (Linking)
VI  - 316
IP  - 2-3
DP  - 1996 Dec 5
TI  - Involvement of NMDA receptor in the regulation of plasma interleukin-6 levels in 
      mice.
PG  - 165-9
AB  - MK-801 ((+)-5-methyl-10,11-dihydro-5H-dibenzo(a,d)cyclopepten-5,10-imine 
      maleate), a non-competitive NMDA receptor antagonist (0.01-1 micrograms), 
      injected intracerebroventricularly (i.c.v.) dose dependently increased the 
      baseline levels of plasma interleukin-6 in mice. In the 1-h 
      immobilization-stressed animals, MK-801 (1 micrograms) administered i.c.v. 
      produced an additive increase of plasma interleukin-6. NMDA 
      (N-methyl-D-aspartate) (3, 10 ng) administered i.c.v. attenuated dose dependently 
      the 1-h immobilization stress-induced rise in plasma interleukin-6 level. Neither 
      6-cyano-7-nitro-quinoxaline-2,3-dione (CNQX) (0.01-0.5 micrograms) nor 
      alpha-methyl-4-carboxyphenylglycine (MCPG) (1-20 micrograms), antagonists of 
      non-NMDA and metabotropic glutamate receptors, respectively, i.c.v. administered, 
      affected the basal and stress-induced plasma interleukin-6 levels. These data 
      indicate that NMDA receptors may be involved in the suppressive regulation of the 
      plasma interleukin-6 levels.
FAU - Song, D K
AU  - Song DK
AD  - Department of Pharmacology, College of Medicine, Hallym University, Chunchon, 
      Kangwon-Do, South Korea. DKSong@sun.Hallym.ac.kr
FAU - Suh, H W
AU  - Suh HW
FAU - Jung, J S
AU  - Jung JS
FAU - Wie, M B
AU  - Wie MB
FAU - Song, J H
AU  - Song JH
FAU - Kim, Y H
AU  - Kim YH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Eur J Pharmacol
JT  - European journal of pharmacology
JID - 1254354
RN  - 0 (Interleukin-6)
RN  - 0 (Receptors, N-Methyl-D-Aspartate)
RN  - 6384-92-5 (N-Methylaspartate)
RN  - 6LR8C1B66Q (Dizocilpine Maleate)
SB  - IM
MH  - Animals
MH  - Dizocilpine Maleate/pharmacology
MH  - Dose-Response Relationship, Drug
MH  - Interleukin-6/*metabolism
MH  - Male
MH  - Mice
MH  - Mice, Inbred ICR
MH  - N-Methylaspartate/*pharmacology
MH  - Receptors, N-Methyl-D-Aspartate/*physiology
EDAT- 1996/12/05 00:00
MHDA- 1996/12/05 00:01
CRDT- 1996/12/05 00:00
PHST- 1996/12/05 00:00 [pubmed]
PHST- 1996/12/05 00:01 [medline]
PHST- 1996/12/05 00:00 [entrez]
AID - S0014-2999(96)00666-8 [pii]
AID - 10.1016/s0014-2999(96)00666-8 [doi]
PST - ppublish
SO  - Eur J Pharmacol. 1996 Dec 5;316(2-3):165-9. doi: 10.1016/s0014-2999(96)00666-8.