PMID- 8983082
OWN - NLM
STAT- MEDLINE
DCOM- 19970529
LR  - 20181130
VI  - 24
DP  - 1994
TI  - Insights into the physiology of TGF alpha and signaling through the EGF receptor 
      revealed by gene targeting and acts of nature.
PG  - 276-89
AB  - Transforming growth factor alpha (TGF alpha) is one of a group of 
      structurally-related growth factors (the epidermal growth factor family of 
      ligands) that interact with one or other members of the epidermal growth factor 
      family of protein tyrosine kinase receptors (EGF-R's). A number of excellent 
      reviews detailing our knowledge of this area have been recently published 
      (Carpenter and Wahl, 1991; Derynck, 1992; Prigent and Lemoine, 1992). Rather than 
      add to their number, this review focuses on new insights into the importance of 
      TGF alpha and signaling through the EGF receptor considered in the context of the 
      laboratory mouse. The new information has emerged from analysis of mutant mice 
      generated either by classical gene targeting in embryonic stem (ES) cells or by 
      accidents of nature. In addition to their intrinsic interest, these mice are 
      proving invaluable in determining the importance of EGF receptor signaling in 
      wound healing and as a contributing factor in the conversion of a normal cell 
      into its tumorigenic counterpart.
FAU - Dunn, A R
AU  - Dunn AR
AD  - Ludwig Institute for Cancer Research, Royal Melbourne Hospital, Victoria, 
      Australia.
FAU - Mann, G B
AU  - Mann GB
FAU - Fowler, K J
AU  - Fowler KJ
FAU - Grail, D
AU  - Grail D
FAU - Hibbs, M L
AU  - Hibbs ML
FAU - Alexander, W S
AU  - Alexander WS
FAU - Walker, F
AU  - Walker F
FAU - Burgess, A W
AU  - Burgess AW
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Princess Takamatsu Symp
JT  - Princess Takamatsu symposia
JID - 9301172
RN  - 0 (Transforming Growth Factor alpha)
RN  - 57-97-6 (9,10-Dimethyl-1,2-benzanthracene)
RN  - 62229-50-9 (Epidermal Growth Factor)
RN  - EC 2.7.10.1 (ErbB Receptors)
SB  - IM
MH  - 9,10-Dimethyl-1,2-benzanthracene
MH  - Animals
MH  - Cell Transformation, Neoplastic
MH  - Cocarcinogenesis
MH  - Epidermal Growth Factor/physiology
MH  - ErbB Receptors/drug effects/genetics/*physiology
MH  - Gene Targeting
MH  - Hair/growth & development
MH  - Mice
MH  - Mice, Knockout
MH  - Mice, Mutant Strains
MH  - Multigene Family
MH  - Mutagenesis, Insertional
MH  - Papilloma/chemically induced/physiopathology
MH  - Recombination, Genetic
MH  - Signal Transduction/*physiology
MH  - Skin Neoplasms/chemically induced/physiopathology
MH  - Transforming Growth Factor alpha/deficiency/genetics/*physiology
MH  - Vibrissae/growth & development
MH  - Wound Healing/physiology
RF  - 63
EDAT- 1994/01/01 00:00
MHDA- 1994/01/01 00:01
CRDT- 1994/01/01 00:00
PHST- 1994/01/01 00:00 [pubmed]
PHST- 1994/01/01 00:01 [medline]
PHST- 1994/01/01 00:00 [entrez]
PST - ppublish
SO  - Princess Takamatsu Symp. 1994;24:276-89.