PMID- 8985619
OWN - NLM
STAT- MEDLINE
DCOM- 19970411
LR  - 20191101
IS  - 0959-9851 (Print)
IS  - 0959-9851 (Linking)
VI  - 6
IP  - 6
DP  - 1996 Dec
TI  - The effects of lidocaine on cardiac parasympathetic control in normal subjects 
      and in subjects after myocardial infarction.
PG  - 313-9
AB  - It has been widely accepted that lidocaine has little or no effect on the 
      autonomic nervous system. However, we have previously shown that in dogs with 
      vagally induced atrial fibrillation, lidocaine has a pronounced parasympatholytic 
      effect. To study the possible effect of lidocaine on autonomic cardiac control in 
      humans, we performed spectral analysis of heart rate fluctuations in 19 healthy 
      volunteers, who received an i.v. bolus of lidocaine (1.4 mg/kg), as well as in 13 
      patients suffering from acute inferior myocardial infarction (IMI) and 13 
      patients suffering from acute anterior myocardial infarction (AMI), who received 
      therapeutic doses of i.v. lidocaine infusion (4 mg/min). Heart rate variability 
      and respiratory pattern were monitored according to a predetermined protocol, 
      with and without lidocaine. Computing the heart rate power spectrum and 
      integrating over predetermined frequency bands, we focused mainly on the 
      respiratory frequency band, known to predominantly reflect parasympathetic 
      control. The administration of lidocaine resulted in a significant overall 
      increase in mean heart rate: for the healthy control group an increase of 5.5 +/- 
      2.2% (mean +/- SE), for the IMI group an increase of 9.4 +/- 3.5%, and for the 
      AMI group an increase of 8.1 +/- 2.9% (p < 0.01 for all). Simultaneously, 
      following the administration of lidocaine, there was a decrease in the power of 
      respiratory fluctuations: for the healthy control group a decrease of 38.4 +/- 
      12.5%, for the IMI group a decrease of 46.3 +/- 32.9%, and for the AMI group a 
      decrease of 33.9 +/- 16.2% (p < 0.01 for all). These findings indicate that 
      lidocaine has a consistent and significant parasympatholytic effect on the human 
      heart, in healthy volunteers as well as in patients in the acute phase of 
      myocardial infarction.
FAU - Abramovich-Sivan, S
AU  - Abramovich-Sivan S
AD  - Abramson Institute of Medical Physics, Sackler Faculty of Exact Sciences, Tel 
      Aviv University, Israel.
FAU - Bitton, Y
AU  - Bitton Y
FAU - Karin, J
AU  - Karin J
FAU - David, D
AU  - David D
FAU - Akselrod, S
AU  - Akselrod S
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - Clin Auton Res
JT  - Clinical autonomic research : official journal of the Clinical Autonomic Research 
      Society
JID - 9106549
RN  - 0 (Anesthetics, Local)
RN  - 0 (Anti-Arrhythmia Agents)
RN  - 98PI200987 (Lidocaine)
SB  - IM
MH  - Adult
MH  - Anesthetics, Local/*pharmacology
MH  - Anti-Arrhythmia Agents/*pharmacology
MH  - Arrhythmia, Sinus/drug therapy
MH  - Case-Control Studies
MH  - Electrocardiography/drug effects
MH  - Female
MH  - Heart/*drug effects/innervation
MH  - Heart Rate/drug effects
MH  - Humans
MH  - Lidocaine/*pharmacology
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
MH  - Myocardial Infarction/*drug therapy
MH  - Parasympathetic Nervous System/*drug effects
MH  - Reference Values
EDAT- 1996/12/01 00:00
MHDA- 1996/12/01 00:01
CRDT- 1996/12/01 00:00
PHST- 1996/12/01 00:00 [pubmed]
PHST- 1996/12/01 00:01 [medline]
PHST- 1996/12/01 00:00 [entrez]
AID - 10.1007/BF02556301 [doi]
PST - ppublish
SO  - Clin Auton Res. 1996 Dec;6(6):313-9. doi: 10.1007/BF02556301.