PMID- 8990098
OWN - NLM
STAT- MEDLINE
DCOM- 19970319
LR  - 20171116
IS  - 1046-2023 (Print)
IS  - 1046-2023 (Linking)
VI  - 11
IP  - 1
DP  - 1997 Jan
TI  - Tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) in B-lymphocyte 
      function.
PG  - 128-32
AB  - Two cytokines important in the regulation of B-cell function are tumor necrosis 
      factor-alpha (TNF-alpha) and interleukin-6 (IL-6). They act at different steps in 
      B-cell differentiation and can be produced by the B cells themselves upon 
      appropriate stimulation. Crosslinking of surface Ig and signaling through CD22 or 
      CD40 lead to increased secretion of both cytokines. Neutralization of TNF-alpha 
      or IL-6 biologic activity in B-cell cultures results in a significant reduction 
      in B-cell proliferation and Ig secretion. Increased production of these cytokines 
      is found in several diseases associated with aberrant B-cell function. This 
      review will focus on the role of TNF-alpha and IL-6 in normal and 
      pathophysiological conditions of B-cell function.
FAU - Rieckmann, P
AU  - Rieckmann P
AD  - Department of Neurology, Julius-Maximilians Universitat, Wurzburg, Germany.
FAU - Tuscano, J M
AU  - Tuscano JM
FAU - Kehrl, J H
AU  - Kehrl JH
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Methods
JT  - Methods (San Diego, Calif.)
JID - 9426302
RN  - 0 (Antibodies, Monoclonal)
RN  - 0 (Antigens, CD)
RN  - 0 (Antigens, Differentiation, B-Lymphocyte)
RN  - 0 (CD22 protein, human)
RN  - 0 (CD40 Antigens)
RN  - 0 (Cell Adhesion Molecules)
RN  - 0 (Cross-Linking Reagents)
RN  - 0 (Interleukin-6)
RN  - 0 (Lectins)
RN  - 0 (Sialic Acid Binding Ig-like Lectin 2)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Antibodies, Monoclonal/metabolism/pharmacology
MH  - Antigens, CD/immunology/metabolism
MH  - Antigens, Differentiation, B-Lymphocyte/immunology/metabolism
MH  - B-Lymphocytes/drug effects/*metabolism
MH  - CD40 Antigens/metabolism
MH  - *Cell Adhesion Molecules
MH  - Cell Differentiation/drug effects
MH  - Cell Division/drug effects
MH  - Cross-Linking Reagents/metabolism
MH  - Gene Expression Regulation/genetics
MH  - Humans
MH  - Inflammation/metabolism
MH  - Interleukin-6/metabolism/*pharmacology
MH  - *Lectins
MH  - Sialic Acid Binding Ig-like Lectin 2
MH  - Signal Transduction/physiology
MH  - Tumor Necrosis Factor-alpha/metabolism/*pharmacology
EDAT- 1997/01/01 00:00
MHDA- 1997/01/01 00:01
CRDT- 1997/01/01 00:00
PHST- 1997/01/01 00:00 [pubmed]
PHST- 1997/01/01 00:01 [medline]
PHST- 1997/01/01 00:00 [entrez]
AID - S1046-2023(96)90396-5 [pii]
AID - 10.1006/meth.1996.0396 [doi]
PST - ppublish
SO  - Methods. 1997 Jan;11(1):128-32. doi: 10.1006/meth.1996.0396.