PMID- 8990141
OWN - NLM
STAT- MEDLINE
DCOM- 19970128
LR  - 20190822
IS  - 0147-5185 (Print)
IS  - 0147-5185 (Linking)
VI  - 21
IP  - 1
DP  - 1997 Jan
TI  - Fibrosarcoma versus cellular fibroma of the ovary: a comparative study of their 
      proliferative activity and chromosome aberrations using MIB-1 immunostaining, DNA 
      flow cytometry, and fluorescence in situ hybridization.
PG  - 52-9
AB  - We retrospectively analyzed the proliferative activity and the centromeric copy 
      number of chromosomes 8, 12, and 17 in three cases of fibrosarcoma and eight 
      cases of cellular fibroma of the ovary using MIB-1 immunostaining, DNA flow 
      cytometry, and fluorescence in situ hybridization (FISH) on paraffin-embedded 
      tissue specimens. In our study, both the MIB-1 labeling index (LI) and the 
      proliferative index (% of cells in S + G2 + M phase) in fibrosarcomas were higher 
      than those in cellular fibromas. The FISH analysis demonstrated the sole 
      abnormality of a gain of trisomy 12 cells in all eight cases of cellular fibroma. 
      Both a gain of trisomy 12 cells and a gain of tetrasomy 12 cells were observed in 
      one case of fibrosarcoma. A gain of trisomy 8 cells was observed in all two 
      fibrosarcomas in which signals were detected. By contrast, neither a gain of 
      trisomy 8 cells nor a gain of tetrasomy 12 cells was observed in any of the eight 
      cases of cellular fibroma. Chromosome 17 showed disomy in all eleven cases. On 
      the basis of these findings, a gain of trisomy 8 cells is therefore considered to 
      be an adequately effective marker to distinguish between cellular fibroma and 
      fibrosarcoma of the ovary, and it may also be related to the proliferative 
      activity of fibrosarcoma of the ovary.
FAU - Tsuji, T
AU  - Tsuji T
AD  - Second Department of Pathology, Faculty of Medicine, Kyushu University, Fukuoka, 
      Japan.
FAU - Kawauchi, S
AU  - Kawauchi S
FAU - Utsunomiya, T
AU  - Utsunomiya T
FAU - Nagata, Y
AU  - Nagata Y
FAU - Tsuneyoshi, M
AU  - Tsuneyoshi M
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - Am J Surg Pathol
JT  - The American journal of surgical pathology
JID - 7707904
RN  - 0 (Antigens, Nuclear)
RN  - 0 (Autoantigens)
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (DNA, Neoplasm)
RN  - 0 (Ki-67 Antigen)
RN  - 0 (Nuclear Proteins)
SB  - IM
CIN - Am J Surg Pathol. 1998 Apr;22(4):508-10. PMID: 9537481
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Antigens, Nuclear
MH  - Autoantigens/analysis
MH  - Biomarkers, Tumor/analysis
MH  - Cell Division
MH  - Chromosome Aberrations
MH  - DNA, Neoplasm/genetics/ultrastructure
MH  - Female
MH  - Fibroma/chemistry/*genetics/*pathology
MH  - Fibrosarcoma/chemistry/*genetics/*pathology
MH  - Flow Cytometry
MH  - Humans
MH  - Immunoenzyme Techniques
MH  - In Situ Hybridization, Fluorescence
MH  - Ki-67 Antigen
MH  - Middle Aged
MH  - Nuclear Proteins/analysis
MH  - Ovarian Neoplasms/chemistry/*genetics/*pathology
EDAT- 1997/01/01 00:00
MHDA- 1997/01/01 00:01
CRDT- 1997/01/01 00:00
PHST- 1997/01/01 00:00 [pubmed]
PHST- 1997/01/01 00:01 [medline]
PHST- 1997/01/01 00:00 [entrez]
AID - 10.1097/00000478-199701000-00006 [doi]
PST - ppublish
SO  - Am J Surg Pathol. 1997 Jan;21(1):52-9. doi: 10.1097/00000478-199701000-00006.