PMID- 8990774
OWN - NLM
STAT- MEDLINE
DCOM- 19970130
LR  - 20161013
IS  - 0929-6646 (Print)
IS  - 0929-6646 (Linking)
VI  - 95
IP  - 11
DP  - 1996 Nov
TI  - Low-grade gastric B-cell lymphoma of mucosa-associated lymphoid tissue: 
      clinicopathologic analysis of 19 cases.
PG  - 857-65
AB  - Low-grade gastric B-cell lymphoma of mucosa-associated lymphoid tissue type 
      (MALToma) is a recently recognized disease entity. We report the 
      clinicopathologic features of 19 patients with MALToma in Taiwan. The 19 patients 
      included eight men and 11 women, ranging in age from 26 to 77 years, with a mean 
      age of 58.8 years. Most complained of abdominal pain or gastrointestinal 
      bleeding. The endoscopic and gross features of the gastric lesions revealed 
      erosion (flat type), ulceration (depressed type), cobblestone appearance or 
      abnormal gastric folds (elevated type), mimicking chronic gastritis, ulcer or 
      early gastric carcinoma. Typical histopathologic features included 
      lymphoepithelial lesion and extensive mucosal infiltration of centrocyte-like 
      cells in all cases. Clonality analysis of the variable-diversity-joining region 
      of the immunoglobulin gene by semi-nested polymerase chain reaction demonstrated 
      monoclonality in 72% of the cases. Helicobacter pylori bacilli (H. pylori) could 
      be identified on histologic sections in 15 cases (78.9%); the serologic test for 
      H. pylori was positive in 12 of 13 patients tested (92%). In six patients 
      receiving triple therapy (amoxicillin, bismuth subcitrate and metronidazole), 
      five showed significant histologic regression with eradication of H. pylori 4 to 
      6 months after the start of treatment; one patient showed persistent lesions and 
      presence of H. pylori. However, persistence of residual lymphoid cells and 
      monoclonality of the immunoglobulin gene, could still be demonstrated in four 
      cases. Of nine patients treated with surgery or chemotherapy, two died: one due 
      to concomitant gastric carcinoma and the other one due to sudden apnea. No 
      recurrence was observed in the remaining seven patients. The remaining four 
      patients were lost to follow-up. Our experience confirmed that gastric MALToma is 
      a low-grade neoplastic process. The dramatic response of gastric MALToma to 
      anti-H. pylori treatment suggests that H. pylori infection is closely related to 
      the pathogenesis of low-grade gastric MALToma. However, long-term follow-up is 
      mandatory due to the persistence of the monoclonality of the immunoglobulin gene 
      in the residual lymphoid cells after treatment.
FAU - Chiang, I P
AU  - Chiang IP
AD  - Department of Pathology, National Taiwan University Hospital and Medical College, 
      Taipei, Taiwan, ROC.
FAU - Wang, H H
AU  - Wang HH
FAU - Cheng, A L
AU  - Cheng AL
FAU - Lin, J T
AU  - Lin JT
FAU - Su, I J
AU  - Su IJ
LA  - eng
PT  - Journal Article
PL  - Singapore
TA  - J Formos Med Assoc
JT  - Journal of the Formosan Medical Association = Taiwan yi zhi
JID - 9214933
SB  - IM
MH  - Adult
MH  - Aged
MH  - Female
MH  - Follow-Up Studies
MH  - Gene Rearrangement
MH  - Genes, Immunoglobulin
MH  - Helicobacter pylori/isolation & purification
MH  - Humans
MH  - Lymphoma, B-Cell/immunology/*pathology
MH  - Lymphoma, B-Cell, Marginal Zone/immunology/*pathology
MH  - Lymphoma, Non-Hodgkin/immunology/*pathology
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Staging
MH  - Stomach Neoplasms/immunology/*pathology
EDAT- 1996/11/01 00:00
MHDA- 1996/11/01 00:01
CRDT- 1996/11/01 00:00
PHST- 1996/11/01 00:00 [pubmed]
PHST- 1996/11/01 00:01 [medline]
PHST- 1996/11/01 00:00 [entrez]
PST - ppublish
SO  - J Formos Med Assoc. 1996 Nov;95(11):857-65.