PMID- 8992787
OWN - NLM
STAT- MEDLINE
DCOM- 19970110
LR  - 20061115
IS  - 0043-5325 (Print)
IS  - 0043-5325 (Linking)
VI  - 108
IP  - 17
DP  - 1996
TI  - [The testis as eutopic production site of human growth hormone, placental 
      lactogen and prolactin: possible autocrine/paracrine effects on testicular 
      function].
PG  - 541-6
AB  - The human (h) protein hormones, growth hormone (hGH-N) and prolactin (hPRL), are 
      mainly produced in the pituitary, whereas the human placenta expresses the other 
      four members of the protein hormone gene family, designated placental lactogens 
      (PL-A, PL-B, PL-L) and growth hormone variant (GH-V), GH-N stimulates somatic 
      growth, supports nitrogen-, phosphate- and potassium retention and promotes 
      lipolytic and anabolic metabolism, whereas PRL acts on the mammary gland and 
      induces mammogenesis, lactogenesis and galactopoesis. Both hyperprolactinemia and 
      growth hormone deficiency affect the onset of puberty and reproduction in man and 
      mice. In addition to the glycoprotein hormones, these hormones play a role in the 
      maintenance of testicular function. Our group previously demonstrated eutopic 
      production of glycoprotein hormones hLH (human luteinizing hormone) and hCG 
      (human chorionic gonadotropin) in the testis. We have now extended our 
      investigations to the local testicular expression of protein hormones. By means 
      of the molecular biology techniques of the reverse transcription-polymerase chain 
      reaction (RT-PCR), Southern blot and by restriction endonuclease analyses of the 
      generated PCR products we demonstrated the eutopic expression of genes coding for 
      the protein hormones. GH-N gene transcripts were detected only in the pituitary 
      and abundant PL-A/B and a few GH-V gene transcripts were demonstrable in the 
      placenta. In contrast, in the testis GH/PL and PRL genes are transcribed. Since 
      testicular protein hormone gene expression is rather low, these hormones may act 
      locally and not as systemic factors; they presumably modulate the LH/CG-mediated 
      testosterone biosynthesis and/or may act on the spermatogenesis.
FAU - Untergasser, G
AU  - Untergasser G
AD  - Institut fur Biomedizinische Alternsforschung, Osterreichische Akademie der 
      Wissenschaften, Innsbruck.
FAU - Kranewitter, W
AU  - Kranewitter W
FAU - Walser, F
AU  - Walser F
FAU - Madersbacher, S
AU  - Madersbacher S
FAU - Dirnhofer, S
AU  - Dirnhofer S
FAU - Berger, P
AU  - Berger P
LA  - ger
PT  - English Abstract
PT  - Journal Article
TT  - Der Hoden als eutoper Produktionsort von humanem Wachstumshormon, plazentarem 
      Laktogen und Prolaktin: mogliche autokrine/parakrine Wirkungen auf die 
      Hodenfunktion.
PL  - Austria
TA  - Wien Klin Wochenschr
JT  - Wiener klinische Wochenschrift
JID - 21620870R
RN  - 0 (RNA, Messenger)
RN  - 12629-01-5 (Human Growth Hormone)
RN  - 9002-62-4 (Prolactin)
RN  - 9035-54-5 (Placental Lactogen)
SB  - IM
CIN - Wien Klin Wochenschr. 1996;108(17):530-1. PMID: 8992785
MH  - Animals
MH  - Human Growth Hormone/*biosynthesis/genetics
MH  - Humans
MH  - Infant, Newborn
MH  - Male
MH  - Mice
MH  - Pituitary Gland/pathology/physiology
MH  - Placenta/pathology/physiology
MH  - Placental Lactogen/*biosynthesis/genetics
MH  - Polymerase Chain Reaction
MH  - Prolactin/*biosynthesis/genetics
MH  - RNA, Messenger/genetics
MH  - Reference Values
MH  - Testis/pathology/*physiology
EDAT- 1996/01/01 00:00
MHDA- 1996/01/01 00:01
CRDT- 1996/01/01 00:00
PHST- 1996/01/01 00:00 [pubmed]
PHST- 1996/01/01 00:01 [medline]
PHST- 1996/01/01 00:00 [entrez]
PST - ppublish
SO  - Wien Klin Wochenschr. 1996;108(17):541-6.