PMID- 8994305
OWN - NLM
STAT- MEDLINE
DCOM- 19970331
LR  - 20170214
IS  - 0192-6233 (Print)
IS  - 0192-6233 (Linking)
VI  - 24
IP  - 6
DP  - 1996 Nov-Dec
TI  - The retardation of aging by caloric restriction: studies in rodents and primates.
PG  - 742-5
AB  - Caloric restriction (CR), which has been investigated by gerontologists for more 
      than 60 yr, provides the only intervention tested to date in mammals (typically 
      mice and rats) that repeatedly and strongly increases maximum life span while 
      retarding the appearance of age-associated pathologic and biologic changes. 
      Although the large majority of rodent studies have initiated CR early in life 
      (1-3 mo of age), CR started in midadulthood (at 12 mo) also extends maximum life 
      span in mice. Two main questions now face gerontologists investigating CR. By 
      what mechanisms does CR retard aging and disease processes in rodents? There is 
      evidence to suggest that age-associated increases in oxidative damage may 
      represent a primary aging process that is attenuated by CR. Will CR exert similar 
      actions in primates? Studies in rhesus monkeys subjected to CR and limited human 
      epidemiological data support the notion of human translatability. However, no 
      matter what the answers are to these questions, the prolongation of the health 
      span and life span of rodents by CR has major implications for many disciplines, 
      including toxicologic pathology, and raises important questions about the 
      desirability of ad libitum feeding.
FAU - Weindruch, R
AU  - Weindruch R
AD  - Department of Medicine, University of Wisconsin, Madison, USA. 
      rhweindr@facstaff.wisc.edu
LA  - eng
GR  - P01 AG-11915/AG/NIA NIH HHS/United States
GR  - R01 AG-10536/AG/NIA NIH HHS/United States
GR  - RR-00167/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PT  - Review
PL  - United States
TA  - Toxicol Pathol
JT  - Toxicologic pathology
JID - 7905907
SB  - IM
MH  - Aging/*physiology
MH  - Animals
MH  - Energy Intake/*physiology
MH  - Female
MH  - Food Deprivation/*physiology
MH  - Humans
MH  - Macaca mulatta
MH  - Mice
MH  - Mice, Inbred C3H
MH  - Mice, Inbred C57BL
MH  - Rats
MH  - Rats, Inbred BN
MH  - Rats, Inbred F344
MH  - Species Specificity
RF  - 26
EDAT- 1996/11/01 00:00
MHDA- 1996/11/01 00:01
CRDT- 1996/11/01 00:00
PHST- 1996/11/01 00:00 [pubmed]
PHST- 1996/11/01 00:01 [medline]
PHST- 1996/11/01 00:00 [entrez]
AID - 10.1177/019262339602400618 [doi]
PST - ppublish
SO  - Toxicol Pathol. 1996 Nov-Dec;24(6):742-5. doi: 10.1177/019262339602400618.