PMID- 8995168
OWN - NLM
STAT- MEDLINE
DCOM- 19970219
LR  - 20151119
IS  - 0301-0449 (Print)
IS  - 0301-0449 (Linking)
VI  - 27
IP  - 1
DP  - 1997 Jan
TI  - Hypothalamic-pituitary vascularization in pituitary stalk transection syndrome: 
      is the pituitary stalk really transected? The role of gadolinium-DTPA with 
      spin-echo T1 imaging and turbo-FLASH technique.
PG  - 48-53
AB  - We examined 14 patients, aged 10-25 years, with idiopathic hypopituitarism. All 
      presented an ectopic posterior pituitary at the median eminence with a 
      hypoplastic anterior pituitary on magnetic resonance imaging (MRI). Eight 
      patients had isolated growth hormone deficit (IGHD) and six had multiple hormone 
      deficits (MPHD). Unenhanced MRI showed the pituitary stalk, which was extremely 
      thin, in only three patients, while T1-weighted images obtained after intravenous 
      injection of gadopentetate dimeglumine (Gd-DTPA) showed a thin pituitary stalk in 
      seven patients (six with IGHD and one with MPHD), demonstrating a preserved 
      vascular component of the stalk. MRI with Gd-DTPA was more sensitive than 
      unenhanced MRI in detecting the pituitary stalk in patients with hypopituitarism 
      with an ectopic posterior pituitary: the stalk was demonstrated in 50 % of the 
      cases (seven patients), versus 21.4 % (three patients) by unenhanced MRI. The 
      dynamic study of the hypothalamo-hypophyseal axis performed with turbo-FLASH 
      sequences after bolus injection of Gd-DTPA showed the residual anterior pituitary 
      to have arterial enhancement times, which suggests that an arterial system 
      compensates for the absent or diminished blood supply from the portal system, 
      independent of stalk detection.
FAU - Genovese, E
AU  - Genovese E
AD  - Department of Radiology, IRCCS Policlinico S. Matteo, P. le C. Golgi, 1, I-27100 
      Pavia, Italy.
FAU - Maghnie, M
AU  - Maghnie M
FAU - Beluffi, G
AU  - Beluffi G
FAU - Villa, A
AU  - Villa A
FAU - Sammarchi, L
AU  - Sammarchi L
FAU - Severi, F
AU  - Severi F
FAU - Campani, R
AU  - Campani R
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - Pediatr Radiol
JT  - Pediatric radiology
JID - 0365332
RN  - 0 (Contrast Media)
RN  - 0 (Organometallic Compounds)
RN  - 7A314HQM0I (Pentetic Acid)
RN  - AU0V1LM3JT (Gadolinium)
RN  - K2I13DR72L (Gadolinium DTPA)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Child
MH  - *Contrast Media
MH  - Female
MH  - Gadolinium
MH  - Gadolinium DTPA
MH  - Humans
MH  - Hypopituitarism/*diagnosis/etiology
MH  - Hypothalamus, Middle/blood supply/*pathology
MH  - *Magnetic Resonance Imaging
MH  - Male
MH  - *Organometallic Compounds
MH  - Pentetic Acid/*analogs & derivatives
MH  - Pituitary Gland/*abnormalities/blood supply/pathology
EDAT- 1997/01/01 00:00
MHDA- 1997/01/01 00:01
CRDT- 1997/01/01 00:00
PHST- 1997/01/01 00:00 [pubmed]
PHST- 1997/01/01 00:01 [medline]
PHST- 1997/01/01 00:00 [entrez]
AID - 10.1007/s002470050062 [doi]
PST - ppublish
SO  - Pediatr Radiol. 1997 Jan;27(1):48-53. doi: 10.1007/s002470050062.