PMID- 9000504
OWN - NLM
STAT- MEDLINE
DCOM- 19970211
LR  - 20190621
IS  - 0014-5793 (Print)
IS  - 0014-5793 (Linking)
VI  - 400
IP  - 1
DP  - 1997 Jan 2
TI  - Tyrosine phosphorylation and Fcgamma receptor-mediated phagocytosis.
PG  - 11-4
AB  - Phagocytosis of IgG-opsonized particulate material in hematopoietic cells is 
      mediated by Fcgamma receptors (FcgammaRs). Interaction of the receptors with Fc 
      domains of IgG triggers transduction of phagocytic signal in which a key role is 
      played by phosphorylation of tyrosine residues of the receptors. These residues 
      are arranged into a specific motif (immunoreceptor tyrosine-based activation 
      motif; ITAM) which is located either in the cytoplasmic part of FcgammaRIIA or in 
      gamma chains associated with FcgammaRI and FcgammaRIIIA. The conserved tyrosine 
      residues are phosphorylated by, and associate with, tyrosine kinases of Src and 
      Syk families. Coordinated action of these components initiates numerous 
      intracellular events leading finally to local rearrangement of the actin-based 
      cytoskeleton and internalization of the particles.
FAU - Strzelecka, A
AU  - Strzelecka A
AD  - Nencki Institute of Experimental Biology, Department of Cell Biology, Warsaw, 
      Poland.
FAU - Kwiatkowska, K
AU  - Kwiatkowska K
FAU - Sobota, A
AU  - Sobota A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - England
TA  - FEBS Lett
JT  - FEBS letters
JID - 0155157
RN  - 0 (Receptors, IgG)
RN  - 42HK56048U (Tyrosine)
RN  - EC 2.7.10.1 (Receptor Protein-Tyrosine Kinases)
SB  - IM
MH  - Phagocytosis/*physiology
MH  - Phosphorylation
MH  - Receptor Protein-Tyrosine Kinases/metabolism
MH  - Receptors, IgG/*metabolism
MH  - Signal Transduction
MH  - Substrate Specificity
MH  - Tyrosine/*metabolism
RF  - 51
EDAT- 1997/01/02 00:00
MHDA- 1997/01/02 00:01
CRDT- 1997/01/02 00:00
PHST- 1997/01/02 00:00 [pubmed]
PHST- 1997/01/02 00:01 [medline]
PHST- 1997/01/02 00:00 [entrez]
AID - S0014-5793(96)01359-2 [pii]
AID - 10.1016/s0014-5793(96)01359-2 [doi]
PST - ppublish
SO  - FEBS Lett. 1997 Jan 2;400(1):11-4. doi: 10.1016/s0014-5793(96)01359-2.