PMID- 9002178
OWN - NLM
STAT- MEDLINE
DCOM- 19970213
LR  - 20191101
IS  - 0966-0844 (Print)
IS  - 0966-0844 (Linking)
VI  - 10
IP  - 1
DP  - 1997 Jan
TI  - Proferrorosamines and phytopathogenicity in Erwinia spp.
PG  - 1-10
AB  - Proferrorosamine A (pFR A) of the plant pathogenic bacterium Erwinia rhapontici 
      was shown to inhibit growth of wheat and cress seedlings at the > or = 10 ppm 
      level. When the seeds were continuously exposed to 100 ppm pFR A, the germination 
      of cress and wheat seeds was inhibited up to 90% and 80%, respectively. The 
      inhibition could be reversed through addition of equimolar amounts of ferrous 
      iron, which indicates that the strong iron chelating capability of pFR A is 
      responsible for the observed effect. The Fe(II) in the corresponding iron 
      complex, ferrorosamine A, was found to be remarkably resistant towards oxidation 
      by hydrogen peroxide and therefore redox-cycling in the Haber-Weiss cycle. It is 
      thus conceivable that pFR A may also attenuate the generation of reactive 
      hydroxyl radicals during the resistant and would reaction. The apparent 
      correlation between proferrorosamine production and virulence in erwiniae was 
      further corroborated through the analysis of Erwinia persicinus, a newly 
      described species. Using electrospray ionization mass spectrometry, E. persicinus 
      was shown to produce pFR A and pFR B, and preliminary evidence for the 
      phytopathogenicity of E. persicinus was found in cress. Inhibition of wheat 
      seedlings by E. persicinus could not be demonstrated, but this may be due to 
      technical difficulties or different host specificities. Taken together, our 
      results indicate that the phytopathogenicity of E. rhapontici and E. persicinus 
      may, as least in part, be due to the release of proferrorosamines.
FAU - Feistner, G J
AU  - Feistner GJ
AD  - Beckman Research Institute of the City of Hope, Duarte, CA, USA. 
      gfeistner@aol.com
FAU - Mavridis, A
AU  - Mavridis A
FAU - Rudolph, K
AU  - Rudolph K
LA  - eng
GR  - CA33572/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Netherlands
TA  - Biometals
JT  - Biometals : an international journal on the role of metal ions in biology, 
      biochemistry, and medicine
JID - 9208478
RN  - 0 (Pyrroles)
RN  - 26927-08-2 (proferrorosamine A)
RN  - BBX060AN9V (Hydrogen Peroxide)
SB  - IM
MH  - Erwinia/*pathogenicity
MH  - Hydrogen Peroxide/pharmacology
MH  - Pyrroles/*toxicity
EDAT- 1997/01/01 00:00
MHDA- 1997/01/01 00:01
CRDT- 1997/01/01 00:00
PHST- 1997/01/01 00:00 [pubmed]
PHST- 1997/01/01 00:01 [medline]
PHST- 1997/01/01 00:00 [entrez]
AID - 10.1023/a:1018397031232 [doi]
PST - ppublish
SO  - Biometals. 1997 Jan;10(1):1-10. doi: 10.1023/a:1018397031232.