PMID- 9002963
OWN - NLM
STAT- MEDLINE
DCOM- 19970224
LR  - 20210216
IS  - 0006-4971 (Print)
IS  - 0006-4971 (Linking)
VI  - 89
IP  - 2
DP  - 1997 Jan 15
TI  - Frequent jumping translocations of chromosomal segments involving the ABL 
      oncogene alone or in combination with CD3-MLL genes in secondary leukemias.
PG  - 596-600
AB  - Seven secondary leukemia patients were treated for solid tumors or malignant 
      lymphoma with anticancer drugs or radiation. We studied bone marrow samples from 
      these patients by fluorescence in situ hybridization (FISH). Of the seven 
      patients, three had increased signals for the ABL oncogene (9q34) on interphase 
      nuclei and at metaphase. One of the three patients also had four signals for the 
      CD3 (MLL) region (11q23). Whole painting probes revealed that these chromosomal 
      regions were translocated onto structurally abnormal chromosomes, resulting in 
      partial tri-, tetra- or penta-somy of these regions. We called this type of 
      translocation "segmental jumping translocation (SJT)." SJT of the ABL oncogene 
      was not detected in samples from 15 patients with de novo acute myelocytic 
      leukemia (AML), 12 with myelodysplastic syndrome (MDS), or 20 with chronic 
      myelocytic leukemia (CML) at the chronic phase. Furthermore, monosomy 7 was also 
      found in the patients with the gene amplification. These results indicate that 
      SJT of ABL and/or CD3 (MLL) genes is associated with the leukemogenesis of 
      secondary leukemia. The SJT may be one mechanism of gene amplification.
FAU - Tanaka, K
AU  - Tanaka K
AD  - Department of Cancer Cytogenetics, Hiroshima University, Japan.
FAU - Arif, M
AU  - Arif M
FAU - Eguchi, M
AU  - Eguchi M
FAU - Kyo, T
AU  - Kyo T
FAU - Dohy, H
AU  - Dohy H
FAU - Kamada, N
AU  - Kamada N
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Blood
JT  - Blood
JID - 7603509
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - *Chromosomes, Human, Pair 11
MH  - *Chromosomes, Human, Pair 7
MH  - Female
MH  - Genes, abl/*genetics
MH  - Humans
MH  - Karyotyping
MH  - Leukemia, Radiation-Induced/*genetics/pathology
MH  - Male
MH  - Middle Aged
MH  - Neoplasms, Second Primary/*genetics/pathology
MH  - *Translocation, Genetic
EDAT- 1997/01/15 00:00
MHDA- 1997/01/15 00:01
CRDT- 1997/01/15 00:00
PHST- 1997/01/15 00:00 [pubmed]
PHST- 1997/01/15 00:01 [medline]
PHST- 1997/01/15 00:00 [entrez]
AID - S0006-4971(20)76761-3 [pii]
PST - ppublish
SO  - Blood. 1997 Jan 15;89(2):596-600.