PMID- 9009252
OWN - NLM
STAT- MEDLINE
DCOM- 19970224
LR  - 20190826
IS  - 0145-2126 (Print)
IS  - 0145-2126 (Linking)
VI  - 20
IP  - 11-12
DP  - 1996 Nov-Dec
TI  - Failure of cyclosporine to induce graft-vs-host disease or graft-vs-leukemia 
      after syngeneic bone marrow transplantation in mice.
PG  - 941-6
AB  - Cyclosporine administration can result in graft-vs-host disease (GVHD) after 
      syngeneic or autologous bone marrow transplantation (BMT). However, data on its 
      anti-tumor effects are limited. We have tried to produce cyclosporine-induced 
      GVHD or graft-vs-leukemia (GVL) against two Ia-bearing murine leukemias. BALB/c 
      mice undergoing syngeneic BMT after total-body irradiation received 1 mg/kg or 10 
      mg/kg cyclosporine or dextrose intraperitoneally for 30 days post-transplant, 
      followed by 5 x 10(3) BCL1 murine leukemia cells 1 or 3 weeks after stopping 
      cyclosporine. Similarly, SJL/J mice undergoing syngeneic BMT received 10 mg/kg 
      cyclosporine or dextrose intraperitoneally for 30 days post-transplant, and were 
      inoculated with 5 x 10(3) or 10(5) murine acute myeloid leukemia (mAML) cells 3 
      weeks after stopping cyclosporine. No clinical or histological evidence of GVHD 
      was seen, and leukemia-free and overall survival was similar with cyclosporine 
      and dextrose. We conclude that under the experimental conditions used, it is not 
      possible to induce syngeneic GVHD with cyclosporine in BALB/c or SJL/J mice. In 
      the absence of GVHD, this approach is also not associated with any GVL effect 
      against murine leukemias BCL1 and mAML.
FAU - Singhal, S
AU  - Singhal S
AD  - Department of Bone Marrow Transplantation, Hadassah University Hospital, 
      Jerusalem, Israel.
FAU - Vourka-Karussis, U
AU  - Vourka-Karussis U
FAU - Mehta, J
AU  - Mehta J
FAU - Slavin, S
AU  - Slavin S
FAU - Weiss, L
AU  - Weiss L
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Leuk Res
JT  - Leukemia research
JID - 7706787
RN  - 83HN0GTJ6D (Cyclosporine)
SB  - IM
MH  - Animals
MH  - Bone Marrow Transplantation/*immunology
MH  - Cyclosporine/*therapeutic use/toxicity
MH  - Female
MH  - Graft vs Host Disease/*chemically induced
MH  - Leukemia, B-Cell/immunology/therapy
MH  - Leukemia, Experimental/immunology/*therapy
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Mice, Inbred Strains
MH  - Neoplasm Transplantation
MH  - Radiation Chimera
MH  - T-Lymphocyte Subsets/transplantation
MH  - Whole-Body Irradiation
EDAT- 1996/11/01 00:00
MHDA- 1996/11/01 00:01
CRDT- 1996/11/01 00:00
PHST- 1996/11/01 00:00 [pubmed]
PHST- 1996/11/01 00:01 [medline]
PHST- 1996/11/01 00:00 [entrez]
AID - S0145-2126(96)00064-1 [pii]
AID - 10.1016/s0145-2126(96)00064-1 [doi]
PST - ppublish
SO  - Leuk Res. 1996 Nov-Dec;20(11-12):941-6. doi: 10.1016/s0145-2126(96)00064-1.