PMID- 9012116
OWN - NLM
STAT- MEDLINE
DCOM- 19970205
LR  - 20061115
IS  - 0042-773X (Print)
IS  - 0042-773X (Linking)
VI  - 42
IP  - 11
DP  - 1996 Nov
TI  - [Plasma and tissue levels of cytokines and adhesive molecules in patients before 
      strumectomy].
PG  - 747-50
AB  - From a group of 134 patients with complete documentation before goitrectomy the 
      authors selected 10 histologically defined cases of (A) simple colloid nodular 
      goitre, (B) toxic parenchymatous goitre type GB and (C) autoimmune thyroiditis. 
      Marked hormonal suppression was achieved in group B by thyrostatic therapy, as 
      compared with A and C, the autoantibody titres (TGAb and TMAb) differentiated the 
      groups. The authors examined the interleukin 6 concentrations and those of its 
      soluble receptor (IL-6, IL-6R), of the tumour necrotizing factor alpha 
      (TNF-alpha) interferon gamma (IFN-gamma) and of adhesion molecules ICAM-1 and 
      VCAM-1. Plasma values were, except for not very significant differences, similar 
      in all groups and ruled out a marked effect on tissue levels. The most remarkable 
      finding in the homogenate of a peroperative excision were low IL-6, IL-6R and 
      adhesion molecule values in group A, as compared with B and C and the absence of 
      differences in TNF-alpha values between groups and in particular markedly higher 
      IFN-gamma values in group B which supports theories on the etiopathogenetic role 
      of this cytokine in GB disease. The pilot study is part of the preparation of in 
      situ hybridization of mRNA for diagnostically usable cytokines.
FAU - Masek, Z
AU  - Masek Z
AD  - Oddeleni klinicke biochemie VFN a 1. LF UK, Praha.
FAU - Astl, J
AU  - Astl J
FAU - Duskova, J
AU  - Duskova J
FAU - Bilek, R
AU  - Bilek R
FAU - Novak, Z
AU  - Novak Z
FAU - Vanik, P
AU  - Vanik P
FAU - Vlasicova, K
AU  - Vlasicova K
FAU - Betka, J
AU  - Betka J
FAU - Schneiderka, P
AU  - Schneiderka P
LA  - cze
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
TT  - Plazmaticke a tkanove koncentrace cytokinu a adhezivnich molekul u pacientu pred 
      strumektomii.
PL  - Czech Republic
TA  - Vnitr Lek
JT  - Vnitrni lekarstvi
JID - 0413602
RN  - 0 (Cell Adhesion Molecules)
RN  - 0 (Cytokines)
SB  - IM
MH  - Cell Adhesion Molecules/*metabolism
MH  - Cytokines/*metabolism
MH  - Female
MH  - Goiter/metabolism/*surgery
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Thyroiditis, Autoimmune/metabolism/surgery
EDAT- 1996/11/01 00:00
MHDA- 1996/11/01 00:01
CRDT- 1996/11/01 00:00
PHST- 1996/11/01 00:00 [pubmed]
PHST- 1996/11/01 00:01 [medline]
PHST- 1996/11/01 00:00 [entrez]
PST - ppublish
SO  - Vnitr Lek. 1996 Nov;42(11):747-50.