PMID- 9013834
OWN - NLM
STAT- MEDLINE
DCOM- 19970310
LR  - 20190722
IS  - 0046-8177 (Print)
IS  - 0046-8177 (Linking)
VI  - 28
IP  - 1
DP  - 1997 Jan
TI  - Subacute cutaneous lupus erythematosus arising in the setting of calcium channel 
      blocker therapy.
PG  - 67-73
AB  - After 6 months to 5 years of calcium channel blocker (CCB) therapy for arterial 
      hypertension, nine patients developed photoinduced annular or papulosquamous 
      eruptions consonant clinically with subacute cutaneous lupus erythematosus 
      (SCLE). Four patients were receiving diltiazem, four received verapamil, and one 
      was taking nifedipine. Serology showed antinuclear antibodies (ANA) in seven of 
      nine patients, anti-Ro antibodies in five, and anti-La antibodies in five, with 
      three patients having only anti-La antibodies. Skin biopsy specimens in all nine 
      patients were held to be characteristic of SCLE based on light microscopy, 
      direct, and indirect immunofluorescence. The CCB was discontinued in all; in 8 
      patients in whom the CCB was stopped, the eruption resolved. A proposed mechanism 
      by which the CCBs may have precipitated the eruptions is offered.
FAU - Crowson, A N
AU  - Crowson AN
AD  - Department of Laboratories, Misericordia General Hospital, Winnipeg, Manitoba, 
      Canada.
FAU - Magro, C M
AU  - Magro CM
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Hum Pathol
JT  - Human pathology
JID - 9421547
RN  - 0 (Calcium Channel Blockers)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Calcium Channel Blockers/*adverse effects
MH  - Female
MH  - Humans
MH  - Lupus Erythematosus, Cutaneous/*chemically induced/diagnosis
MH  - Male
MH  - Middle Aged
EDAT- 1997/01/01 00:00
MHDA- 1997/01/01 00:01
CRDT- 1997/01/01 00:00
PHST- 1997/01/01 00:00 [pubmed]
PHST- 1997/01/01 00:01 [medline]
PHST- 1997/01/01 00:00 [entrez]
AID - S0046-8177(97)90281-1 [pii]
AID - 10.1016/s0046-8177(97)90281-1 [doi]
PST - ppublish
SO  - Hum Pathol. 1997 Jan;28(1):67-73. doi: 10.1016/s0046-8177(97)90281-1.